Author

L. T. Gray

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2 Organism:human· 1 Assay:protein structure· 1

Frequent Co-Authors

A. Solanki· 4 shared A. T. Alpar· 4 shared S. Cao· 4 shared E. Budina· 3 shared R. P. Wallace· 3 shared A. C. Tremain· 2 shared A. Mansurov· 2 shared B. Manicassamy· 2 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersBioengineering

A. Solanki

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Author profile →

4 papers

Recent·Most cited

Engineered Flt3L Drives Tolerogenic State to Attenuate Anti-drug Antibody Responses

A. T. Alpar, R. P. Wallace, K. C. Refvik, S. Gomes, A. Solanki, L. T. Gray, A. J. Slezak, A. L. Lauterbach, L. A. Hesser, S. Cao, J. E. G. Medellin, L. G. Robinson, J. A. Hubbell

The paper describes a method using engineered Flt3L to induce a tolerogenic immune state, reducing anti-drug antibodies to a fungal enzyme.

bioRxiv · Mar 21, 2024 · PreprintBioengineering

Engineered collagen-targeting therapeutics reverse lung and kidney fibrosis in mice

M. J. V. WHITE, M. Raczy, E. Budina, A. Solanki, Z. J. Zhang, L. T. Gray, S. Cao, A. T. Alpar, J. Hubbell

This study develops collagen-targeted therapeutics that reduce lung and kidney fibrosis in mice by improving drug delivery and efficacy.

bioRxiv · Jan 4, 2022 · PreprintBioengineering

Polymersomes decorated with SARS-CoV-2 spike protein receptor binding domain elicit robust humoral and cellular immunity

L. R. Volpatti, R. P. Wallace, S. Cao, M. Raczy, R. Wang, L. T. Gray, A. T. Alpar, P. S. Briquez, N. Mitrousis, T. M. Marchell, M. S. Sasso, M. Nguyen, A. Mansurov, E. Budina, A. Solanki, , J. Hubbell

This study develops a subunit nanovaccine using polymersomes decorated with SARS-CoV-2 RBD, showing enhanced neutralizing antibody and T cell responses in mice.

ACS Central Science · Jul 21, 2021Peer-reviewedBioengineering

Generation of potent cellular and humoral immunity against SARS-CoV-2 antigens via conjugation to a polymeric glyco-adjuvant

L. T. Gray, M. M. Raczy, P. S. Briquez, T. M. Marchell, A. T. Alpar, R. P. Wallace, L. R. Volpatti, M. S. Sasso, S. Cao, M. Nguyen, A. Mansurov, E. Budina, E. A. Watkins, A. Solanki, N. Mitrousis, , J. A. Hubbell

This paper demonstrates that conjugating the SARS-CoV-2 Spike protein to a polymeric glyco-adjuvant elicits strong cellular and humoral immune responses in mice.

bioRxiv · May 20, 2021Bioengineering