B. Manicassamy

ISG15-modification of the Arp2/3 complex restricts pathogen spread

This study shows ISG15 modifies the Arp2/3 complex to restrict pathogen spread by slowing actin filament formation and stabilizing structures, but pathogens like Listeria exploit dysregulated ISGylation to enhance spread.

Avian and Human Influenza Viruses Exhibit Distinct Glycoconjugate Receptor Specificities in Human Lung Cells

The paper shows human and avian influenza viruses use different glycoconjugate types for infection, with avian strains using a broader range.

Polymersomes decorated with SARS-CoV-2 spike protein receptor binding domain elicit robust humoral and cellular immunity

This study develops a subunit nanovaccine using polymersomes decorated with SARS-CoV-2 RBD, showing enhanced neutralizing antibody and T cell responses in mice.

Generation of potent cellular and humoral immunity against SARS-CoV-2 antigens via conjugation to a polymeric glyco-adjuvant

This paper demonstrates that conjugating the SARS-CoV-2 Spike protein to a polymeric glyco-adjuvant elicits strong cellular and humoral immune responses in mice.

Host Factor Rab11a is Critical for Efficient Assembly of Influenza A Virus Genomic Segments

This study identifies Rab11a as a critical host factor for influenza A virus genome assembly by facilitating vRNP congregation and specific interactions.

Rab11a mediates cell-cell spread and reassortment of influenza A virus genomes via tunneling nanotubes.

This paper identifies Rab11a's role in facilitating cell-cell spread of influenza A virus genomes via tunneling nanotubes, enabling genome reassortment and bypassing extracellular barriers.

The p150 Isoform of ADAR1 Blocks Sustained RLR signaling and Apoptosis during Influenza Virus Infection

The paper shows that the p150 isoform of ADAR1 prevents sustained RIG-I signaling and apoptosis during influenza virus infection, independent of RNA editing.

Suppression of Cytotoxic T Cell Functions and Decreased Levels of Tissue Resident Memory T cell During H5N1 infection

This study shows that H5N1 influenza virus infection impairs cytotoxic T cell function and reduces tissue resident memory T cells, leading to delayed viral clearance and prolonged illness.