Author

A. Casini

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Bioengineering· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Assay:DNA methylation· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:CRISPR screen· 1

Frequent Co-Authors

A. A. Heidecker· 1 shared A. Cereseto· 1 shared A. Poethig· 1 shared B. Aikman· 1 shared C. Campbell· 1 shared D. Berrar· 1 shared D. F. Browning· 1 shared E. Kheir· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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1 shared paperBiochemistry

A. A. Heidecker

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Eukaryotic-driven directed evolution of Cas9 nucleases

G. V. Ruta, M. Ciciani, E. Kheir, M. D. Gentile, S. Amistadi, A. Casini, A. Cereseto

This study enhances weakly active Cas9 nucleases using a eukaryotic platform, resulting in a 12-fold increase in activity in mammalian cells while maintaining specificity.

bioRxiv · Sep 18, 2023Bioengineering

Organometallic Pillarplexes that bind DNA 4-way Holliday Junctions and Forks.

J. S. Craig, L. Melidis, H. D. Williams, S. J. Dettmer, A. A. Heidecker, P. J. Altmann, S. Guan, C. Campbell, D. F. Browning, R. K. O. Sigel, S. Johannsen, R. T. Egan, B. Aikman, A. Casini, A. Poethig, M. J. Hannon

This paper demonstrates that Au pillarplexes bind open DNA 4-way junctions and rearrange them into Y-shaped forks, with antiproliferative activity in human cells.

bioRxiv · Jan 4, 2023Biochemistry

Identifying and validating the presence of Guanine-Quadruplexes (G4) within the blood fluke parasite Schistosoma mansoni.

H. Craven, R. Bonsignore, V. Lenis, N. Santi, D. Berrar, M. Swain, H. Whiteland, A. Casini, K. Hoffmann

This paper identifies and validates the presence of G-quadruplexes (G4) in the Schistosoma mansoni genome and demonstrates their enrichment in specific genomic regions and pathways.

bioRxiv · Sep 9, 2020Microbiology