Author

H. D. Williams

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Biochemistry· 1

Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 4 Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 2 Assay:metabolomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1

Frequent Co-Authors

L. Spiga· 2 shared A. A. Heidecker· 1 shared A. Casini· 1 shared A. Grundling· 1 shared A. Poethig· 1 shared B. Aikman· 1 shared C. Campbell· 1 shared C. F. Schuster· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersMicrobiology

L. Spiga

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Laser Desorption Rapid Evaporative Ionisation Mass Spectrometry (LD-REIMS) demonstrates a direct impact of hypochlorous acid stress on PQS-mediated quorum sensing in Pseudomonas aeruginosa

R. Bradley, D. Simon, L. Spiga, Y. Xiang, Z. Takats, H. D. Williams

This paper uses LD-REIMS to show HOCl stress reduces PQS quorum sensing and virulence factors in P. aeruginosa.

bioRxiv · Oct 11, 2023 · PreprintMicrobiology

Organometallic Pillarplexes that bind DNA 4-way Holliday Junctions and Forks.

J. S. Craig, L. Melidis, H. D. Williams, S. J. Dettmer, A. A. Heidecker, P. J. Altmann, S. Guan, C. Campbell, D. F. Browning, R. K. O. Sigel, S. Johannsen, R. T. Egan, B. Aikman, A. Casini, A. Poethig, M. J. Hannon

This paper demonstrates that Au pillarplexes bind open DNA 4-way junctions and rearrange them into Y-shaped forks, with antiproliferative activity in human cells.

bioRxiv · Jan 4, 2023Biochemistry

A universal stress protein acts as a metabolic rheostat controlling carbon flux in mycobacteria

K. E. Lougheed, M. Thomson, L. S. Koziej, G. Larrouy-Maumus, H. D. Williams

This study identifies a universal stress protein in mycobacteria that regulates carbon flux by acting as a metabolic rheostat, demonstrated through 13C-stable isotope tracing and protein interactions.

bioRxiv · Jun 10, 2022 · PreprintMicrobiology

Response of Pseudomonas aeruginosa to the innate immune system-derived oxidants hypochlorous acid and hypothiocyanous acid

K. V. Farrant, L. Spiga, J. C. Davies, H. D. Williams

This study identifies RclR as a key regulator of Pseudomonas aeruginosa's response to HOCl and HOSCN, revealing its role in upregulating stress response genes and coordinating survival mechanisms.

bioRxiv · Jan 9, 2020Microbiology

Cyclic-di-adenosine monophosphate (c-di-AMP) is required for osmotic regulation in Staphylococcus aureus but dispensable for viability in anaerobic conditions

M. S. Zeden, C. F. Schuster, L. Bowman, Q. Zhong, H. D. Williams, A. Grundling

This study identifies c-di-AMP's role in osmotic regulation in S. aureus but shows it is not required for anaerobic growth.

bioRxiv · Jan 5, 2018Microbiology