Author

R. K. O. Sigel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Assay:fluorescence / live-cell microscopy· 2 Organism:human· 2 Approach:statistical model· 2 Approach:benchmark study· 1 Research Focus:benchmarking· 1 Organism:chicken / avian· 1

Frequent Co-Authors

S. Johannsen· 2 shared A. A. Heidecker· 1 shared A. Barth· 1 shared A. Casini· 1 shared A. Poethig· 1 shared B. Aikman· 1 shared B. Masquida· 1 shared C. A. M. Seidel· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersBiochemistry

S. Johannsen

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Author profile →

4 papers

Recent·Most cited

FRET-guided modeling of nucleic acids

F. D. Steffen, R. A. Cunha, R. K. O. Sigel, R. Borner

This paper introduces a framework that integrates single-molecule FRET measurements with molecular dynamics simulations and de novo structure prediction to improve RNA structure modeling.

bioRxiv · Aug 7, 2023Biophysics

Organometallic Pillarplexes that bind DNA 4-way Holliday Junctions and Forks.

J. S. Craig, L. Melidis, H. D. Williams, S. J. Dettmer, A. A. Heidecker, P. J. Altmann, S. Guan, C. Campbell, D. F. Browning, R. K. O. Sigel, S. Johannsen, R. T. Egan, B. Aikman, A. Casini, A. Poethig, M. J. Hannon

This paper demonstrates that Au pillarplexes bind open DNA 4-way junctions and rearrange them into Y-shaped forks, with antiproliferative activity in human cells.

Journal of the American Chemical Society · Jun 15, 2023Peer-reviewedBiochemistry

Anticodon-like loop-mediated dimerization in the crystal structures of HDV- like CPEB3 ribozymes

I. Przytula-Mally, S. Engilberge, S. Johannsen, V. Olieric, B. Masquida, R. K. O. Sigel

The paper presents crystal structures of human and chimpanzee CPEB3 ribozymes, revealing an anticodon-like loop-mediated dimerization mechanism and linking structural features to sequence specificities.

bioRxiv · Sep 22, 2022 · PreprintBiophysics

Inferring kinetic rate constants from single-molecule FRET trajectories - a blind benchmark of kinetic analysis tools

M. Götz, A. Barth, S. S.- R. Bohr, R. Börner, J. Chen, T. Cordes, D. A. Erie, C. Gebhardt, M. C. A. S. Hadzic, G. L. Hamilton, N. S. Hatzakis, T. Hugel, L. Kisley, D. C. Lamb, C. de Lannoy, , S. Schmid

This study benchmarks eleven tools for inferring kinetic rate constants from smFRET trajectories using simulated and experimental data with varying challenges.

bioRxiv · Nov 23, 2021Biophysics