Author

H. Whiteland

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Zoology· 2 Microbiology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Research Focus:cell type annotation· 1 Assay:DNA methylation· 1 Organism:mouse· 1 Organism:non-human primate· 1 Approach:statistical model· 1

Frequent Co-Authors

K. F. Hoffmann· 3 shared J. Forde-Thomas· 2 shared A. Brancale· 1 shared A. Casini· 1 shared A. Coghlan· 1 shared A. Crusco· 1 shared A. E. Marriott· 1 shared A. J. Russell· 1 shared

Activity by Year

2019-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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3 shared papersZoology

K. F. Hoffmann

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Structural requirements for dihydrobenzoxazepinone anthelmintics: actions against medically important and model parasites - Trichuris muris, Brugia malayi, Heligmosomoides polygyrus and Schistosoma mansoni

F. A. Partridge, C. J. Bataille, R. Forman, A. E. Marriott, J. Forde-Thomas, C. Häberli, R. L. Dinsdale, J. D. O'Sullivan, N. J. Willis, G. M. Wynne, H. Whiteland, J. Archer, A. Steven, J. D. Turner, J. Keiser, , D. B. Sattelle

The paper investigates the structure-activity relationship of dihydrobenzoxazepinone (DHB) compounds against various parasitic nematodes and trematodes, identifying key structural features for anthelmintic activity.

ACS Infectious Diseases · Apr 2, 2021Peer-reviewedPharmacology & Toxicology

Identifying and validating the presence of Guanine-Quadruplexes (G4) within the blood fluke parasite Schistosoma mansoni.

H. Craven, R. Bonsignore, V. Lenis, N. Santi, D. Berrar, M. Swain, H. Whiteland, A. Casini, K. Hoffmann

This paper identifies and validates the presence of G-quadruplexes (G4) in the Schistosoma mansoni genome and demonstrates their enrichment in specific genomic regions and pathways.

bioRxiv · Sep 9, 2020Microbiology

Quorum sensing N-Acyl homoserine lactones are a new class of anti-schistosomal.

H. Whiteland, A. Crusco, J. Tibble-Howlings, J. Forde Thomas, L. W. Bloemberg, A. Coghlan, P. Murphy, K. F. Hoffmann

This study identifies N-acyl homoserine lactones as a new class of anti-schistosomal compounds with activity against all schistosome lifecycle stages and some antimicrobial effects against Gram+ and Gram- bacteria.

bioRxiv · Jul 24, 2020Zoology

The repositioning of epigenetic probes/inhibitors identifies new anti-schistosomal lead compounds and chemotherapeutic targets

K. Whatley, G. Padalino, H. Whiteland, K. Geyer, B. Hulme, I. Chalmers, J. Forde-Thomas, S. Ferla, A. Brancale, K. F. Hoffmann

This paper screens epigenetic probes/inhibitors against Schistosoma mansoni and identifies compounds targeting histone methylation/demethylation processes as potential anti-schistosomal agents.

bioRxiv · Aug 8, 2019Zoology