Author

A. D Alessandro

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

H. J. Park· 1 shared J. DeGregori· 1 shared K. C. Hansen· 1 shared M. A. Gregory· 1 shared S. Gehrke· 1 shared T. Nemkov· 1 shared V. Zaberezhnyy· 1 shared

Activity by Year

2018-2018 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 21 mutual co-author links

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1 shared paperCancer Biology

H. J. Park

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1 paper

Recent·Most cited

Targeting glutamine metabolism and redox state for leukemia therapy

M. A. Gregory, T. Nemkov, V. Zaberezhnyy, H. J. Park, S. Gehrke, K. C. Hansen, A. D Alessandro, J. DeGregori

This study shows that inhibiting glutaminase with CB-839 reduces glutathione and increases mitochondrial ROS in AML, leading to apoptosis, and that combining it with pro-oxidant drugs enhances cell death in AML and ALL.

bioRxiv · Apr 18, 2018Cancer Biology