H. J. Park

Rafting a waterfall: Artificial selection for collective composition can succeed or fail depending on the initial and target values

This paper shows that artificial selection of microbial collectives can succeed or fail based on initial and target frequencies, with intermediate targets being hardest to achieve.

Therapeutic resistance in acute myeloid leukemia cells is mediated by a novel ATM/mTOR pathway regulating oxidative phosphorylation

The paper shows that marrow-mediated activation of ATM and mTOR increases oxidative phosphorylation, leading to resistance in FLT3 mutant AML cells, and that combining mTOR and FLT3 inhibitors reduces tumor burden.

A Calcium/Palmitoylation Switch Interfaces the Signaling Networks of Stress Response and Transition to Flowering

The paper identifies a calcium/palmitoylation switch mechanism that regulates flowering time and stress adaptation in plants by controlling the nuclear localization of SOS3/CBL4.

Evolution of irreversible somatic differentiation

This study develops an evolutionary model showing that costly cell differentiation, beneficial vegetative cells, and sufficient organism size are necessary for irreversible somatic differentiation.

A three-dimensional Air-Liquid Interface Culture Model for the Study of Epstein-Barr virus Infection in the Nasopharynx

This study uses a 3D air-liquid interface culture model to show that nasopharyngeal epithelial cells can be infected by EBV, with single-cell RNA-sequencing identifying distinct EBV transcription profiles.

How sequence populations persist inside a genome

The paper models how sequence populations can persist in bacterial genomes by balancing benefits and costs, showing that horizontal gene transfer and population dynamics play key roles.

Why is cyclic dominance so rare?

The paper investigates why cyclic dominance is rare in nature by showing that it is more likely to emerge when new types are unrelated to existing ones rather than similar.

The birth of a bacterial tRNA gene by large-scale, tandem duplication events

This study shows that tRNA gene sets in bacteria can evolve through large-scale duplications of existing tRNA genes, compensating for the loss of a single-copy gene.

3′-UTR shortening contributes to subtype-specific cancer growth by breaking stable ceRNA crosstalk of housekeeping genes

This study identifies 3′-UTR shortening as a mechanism driving subtype-specific cancer growth by disrupting ceRNA networks involving housekeeping genes in breast cancer.

Eco-evolutionary spatial dynamics of non-linear social dilemmas

The paper studies how non-linear payoffs in public goods games affect cooperation in spatial eco-evolutionary systems, showing that synergy can sustain coexistence where linear models would lead to extinction.

Evolution of simple multicellular life cycles in dynamic environments

This study develops a framework to analyze how simple multicellular life cycles evolve in dynamic environments, finding that deterministic reproduction modes are favored over stochastic ones.

Targeting glutamine metabolism and redox state for leukemia therapy

This study shows that inhibiting glutaminase with CB-839 reduces glutathione and increases mitochondrial ROS in AML, leading to apoptosis, and that combining it with pro-oxidant drugs enhances cell death in AML and ALL.

Ecological feedback on diffusion dynamics

The paper analyzes how ecological and evolutionary dynamics interact through spatial diffusion in public goods games, showing their mutual influence on system outcomes.