J. DeGregori

Inflammation promotes aging-associated oncogenesis in the lung.

This study investigates how aging-related inflammation contributes to lung cancer development by analyzing gene expression data and using mouse models to assess the role of inflammation in oncogenesis.

Therapeutic resistance in acute myeloid leukemia cells is mediated by a novel ATM/mTOR pathway regulating oxidative phosphorylation

The paper shows that marrow-mediated activation of ATM and mTOR increases oxidative phosphorylation, leading to resistance in FLT3 mutant AML cells, and that combining mTOR and FLT3 inhibitors reduces tumor burden.

In silico experiments uncover a novel mechanism underlying mutation rate evolution in sexually reproducing populations

This study uses in silico experiments to show that mutation rates in sexual populations can evolve higher or lower depending on selection pressures and genetic factors.

Transcription factor PU.1 enforces quiescence and limits hematopoietic stem cell expansion during inflammatory stress

This study shows that PU.1 enforces HSC quiescence by repressing protein synthesis and cell cycle genes, preventing clonal expansion during inflammatory stress.

Chronic Interleukin-1 exposure triggers selective expansion of Cebpa-deficient multipotent hematopoietic progenitors

This study shows chronic IL-1β exposure selects for Cebpa-deficient HSPC by promoting myeloid differentiation and repressing stem cell programs, linking chronic inflammation to hematologic disorders.

A somatic evolutionary model of the dynamics of aneuploid cells during hematopoietic reconstitution

This paper uses Monte Carlo modeling to show that aneuploid cell frequency peaks after bone marrow transplantation due to reduced purifying selection from population expansion and radiation-induced niche damage.

Somatic maintenance impacts the evolution of mutation rate

This study shows that somatic maintenance and longevity influence mutation rate evolution by modulating the cost of somatic mutations through stochastic modeling.

Targeting glutamine metabolism and redox state for leukemia therapy

This study shows that inhibiting glutaminase with CB-839 reduces glutathione and increases mitochondrial ROS in AML, leading to apoptosis, and that combining it with pro-oxidant drugs enhances cell death in AML and ALL.

A generalized theory of somatic evolution

This study uses Monte Carlo modeling to show that the Multi-Stage Model of Carcinogenesis needs modification to explain cancer incidence and stem cell clonality.