Author

S. Gehrke

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:machine learning (classical)· 1

Frequent Co-Authors

A. D Alessandro· 1 shared E. Rosta· 1 shared G. Bottegoni· 1 shared G. Mandana· 1 shared H. J. Park· 1 shared J. DeGregori· 1 shared K. C. Hansen· 1 shared M. A. Gregory· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperCancer Biology

A. D Alessandro

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2 papers

Recent·Most cited

Investigating the Unbinding of Muscarinic Antagonists from the Muscarinic 3 Receptor.

P. J. Buigues, S. Gehrke, M. Badaoui, G. Mandana, T. Qi, G. Bottegoni, E. Rosta

This paper investigates the unbinding mechanism of muscarinic antagonists from hMR3, identifying structural bottlenecks and key residues involved in the process.

bioRxiv · Jan 3, 2023Biophysics

Targeting glutamine metabolism and redox state for leukemia therapy

M. A. Gregory, T. Nemkov, V. Zaberezhnyy, H. J. Park, S. Gehrke, K. C. Hansen, A. D Alessandro, J. DeGregori

This study shows that inhibiting glutaminase with CB-839 reduces glutathione and increases mitochondrial ROS in AML, leading to apoptosis, and that combining it with pro-oxidant drugs enhances cell death in AML and ALL.

bioRxiv · Apr 18, 2018Cancer Biology