Author

T. Mrozowich

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:biophysical modeling· 2 Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 2 Approach:statistical model· 2 Organism:virus· 2 Approach:deep learning· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

T. R. Patel· 5 shared A. Henrickson· 4 shared B. Demeler· 4 shared M. D. Badmalia· 2 shared M. T. Wolfinger· 2 shared S. Tersteeg· 2 shared A. De Klerk· 1 shared A. Frederickson· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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5 shared papersBiochemistry

T. R. Patel

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Author profile →

5 papers

Recent·Most cited

Purification and Characterization of Inorganic Pyrophosphatase for in vitro RNA Transcription

S. Tersteeg, T. Mrozowich, A. Henrickson, B. Demeler, T. R. Patel

This paper demonstrates a cost-effective method to produce high-quality inorganic pyrophosphatase for in vitro RNA transcription, showing it is as effective as commercial versions and revealing its oligomeric structure.

bioRxiv · Apr 12, 2022Biochemistry

Investigating RNA-RNA interactions through computational and biophysical analysis

T. Mrozowich, S. M. Park, M. Waldl, A. Henrickson, S. Tersteeg, C. R. Nelson, A. De Klerk, B. Demeler, I. L. Hofacker, M. T. Wolfinger, T. R. Patel

This paper computationally predicts and biophysically validates long-range RNA-RNA interactions in JEV, showing the cyclization sequence drives interaction with nM affinity.

bioRxiv · Feb 1, 2022 · PreprintBiochemistry

Biophysical Characterisation of Human LincRNA-p21 Sense and Antisense Alu Inverted Repeats

M. D'Souza, T. Mrozowich, M. D. Badmalia, M. Geeraert, A. Frederickson, A. Henrickson, B. Demeler, M. T. Wolfinger, T. R. Patel

The paper determines the three-dimensional structures of LincRNA-p21 Alu inverted repeats using biophysical methods and integrates secondary structure data to generate high-resolution models.

bioRxiv · Dec 8, 2021Biochemistry

Identification and characterization of a G-quadruplex structure in the pre-core promoter region of hepatitis B virus

V. Meier-Stephenson, M. D. Badmalia, T. Mrozowich, K. C. Lau, S. K. Schultz, D. L. Gemmill, C. Osiowy, G. van Marle, C. S. Coffin, T. R. Patel

This study identifies a conserved G-quadruplex structure in the HBV pre-core promoter region and shows its role in viral replication and potential as a therapeutic target.

bioRxiv · Jan 19, 2021Biophysics

Nanoscale Structure Determination of Murray Valley Encephalitis and Powassan Virus Non-coding RNAs

T. Mrozowich, A. Henrickson, B. Demeler, T. R. Patel

This study examines the 5' and 3' terminal regions of Murray Valley Encephalitis and Powassan virus RNAs using biophysical and computational methods, revealing structural differences between the two regions.

bioRxiv · Jan 10, 2020Biochemistry