T. R. Patel

Zika virus remodels and hijacks IGF2BP2 ribonucleoprotein complex to promote viral replication organelle biogenesis

This study identifies IGF2BP2 as a host factor hijacked by ZIKV to regulate viral replication organelle biogenesis and vRNA synthesis.

Purification and Characterization of Inorganic Pyrophosphatase for in vitro RNA Transcription

This paper demonstrates a cost-effective method to produce high-quality inorganic pyrophosphatase for in vitro RNA transcription, showing it is as effective as commercial versions and revealing its oligomeric structure.

Investigating RNA-RNA interactions through computational and biophysical analysis

This paper computationally predicts and biophysically validates long-range RNA-RNA interactions in JEV, showing the cyclization sequence drives interaction with nM affinity.

Biophysical Characterisation of Human LincRNA-p21 Sense and Antisense Alu Inverted Repeats

The paper determines the three-dimensional structures of LincRNA-p21 Alu inverted repeats using biophysical methods and integrates secondary structure data to generate high-resolution models.

Molecular mechanism of quorum sensing inhibition in Streptococcus by the phage protein paratox

This study elucidates how the phage protein Prx inhibits quorum sensing in Streptococcus pyogenes by inducing conformational changes in the ComR receptor.

Identification and characterization of a G-quadruplex structure in the pre-core promoter region of hepatitis B virus

This study identifies a conserved G-quadruplex structure in the HBV pre-core promoter region and shows its role in viral replication and potential as a therapeutic target.

Bioinformatic Analysis of Structure and Function of LIM Domains of Human Zyxin Family Proteins

The paper performs a bioinformatic analysis of human Zyxin family proteins, revealing their potential nuclear and cytoplasmic roles, structural properties, and interactions.

Nanoscale Structure Determination of Murray Valley Encephalitis and Powassan Virus Non-coding RNAs

This study examines the 5' and 3' terminal regions of Murray Valley Encephalitis and Powassan virus RNAs using biophysical and computational methods, revealing structural differences between the two regions.