Author

C. R. Nelson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Biochemistry· 1 Biophysics· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell signaling & trafficking· 4 Research Focus:chromatin & epigenetic regulation· 3 Research Focus:development & morphogenesis· 3 Organism:C. elegans· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1

Frequent Co-Authors

C. L. Asbury· 3 shared S. Biggins· 3 shared N. Bhalla· 2 shared A. De Klerk· 1 shared A. Donath· 1 shared A. E. Russo· 1 shared A. Henrickson· 1 shared A. R. Lemmon· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 8 mutual co-author links

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3 shared papersCell Biology

C. L. Asbury

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Author profile →

7 papers

Recent·Most cited

Architecture and flexibility of native kinetochores revealed by structural studies utilizing a thermophilic yeast

D. J. Barrero, S. S. Wijeratne, X. Zhao, G. F. Cunningham, R. Yan, C. R. Nelson, Y. Arimura, H. Funabiki, C. L. Asbury, Z. Yu, R. Subramanian, S. Biggins

This study reveals the architecture and flexibility of native kinetochores using structural analyses of purified kinetochores from thermophilic yeast.

bioRxiv · Feb 28, 2024 · PreprintBiophysics

Phylogenomics recovers multiple origins of portable case-making in caddisflies (Insecta: Trichoptera), the world's most common underwater architects

P. B. Frandsen, R. W. Holzenthal, M. Espeland, J. Breinholt, J. A. Thomas, S. Simon, A. Y. Kawahara, D. Plotkin, S. Hotaling, Y. Li, C. R. Nelson, O. Niehuis, C. Mayer, L. Podsiadlowski, A. Donath, , X. Zhou

This study uses phylogenomic data to reconstruct the evolutionary history of caddisflies, finding that portable case-making evolved independently in three lineages.

bioRxiv · Dec 21, 2023Evolutionary Biology

Mechanical coupling coordinates microtubule growth

B. K. Leeds, K. F. Kostello, Y. Y. Liu, C. R. Nelson, S. Biggins, C. L. Asbury

The paper shows mechanical coupling coordinates microtubule growth in vitro using a dual laser trap assay, explaining coordination without free fit parameters.

bioRxiv · Jun 29, 2023 · PreprintCell Biology

Investigating RNA-RNA interactions through computational and biophysical analysis

T. Mrozowich, S. M. Park, M. Waldl, A. Henrickson, S. Tersteeg, C. R. Nelson, A. De Klerk, B. Demeler, I. L. Hofacker, M. T. Wolfinger, T. R. Patel

This paper computationally predicts and biophysically validates long-range RNA-RNA interactions in JEV, showing the cyclization sequence drives interaction with nM affinity.

bioRxiv · Feb 1, 2022 · PreprintBiochemistry

Kinetochore-associated Mps1 regulates the strength of kinetochore-microtubule attachments via Ndc80 phosphorylation

K. K. Sarangapani, L. B. Koch, C. R. Nelson, C. L. Asbury, S. Biggins

This study shows Mps1 weakens kinetochore-microtubule attachments by phosphorylating Ndc80, contributing to error correction during mitosis.

bioRxiv · Apr 25, 2021Cell Biology

PCH-2TRIP13 regulates spindle checkpoint strength

L. Defachelles, A. E. Russo, C. R. Nelson, N. Bhalla

This study shows that PCH-2/TRIP13 regulates spindle checkpoint strength in C. elegans by controlling Mad2 conformation and localization, particularly in germline precursor cells.

bioRxiv · May 15, 2020Cell Biology

Shugoshin is essential for meiotic prophase checkpoints in C. elegans

T. Bohr, C. R. Nelson, S. Giacopazzi, P. Lamelza, N. Bhalla

This study shows that SGO-1, the C. elegans Shugoshin ortholog, is essential for meiotic prophase checkpoints, with roles similar to HTP-3 in regulating chromosome structure and DNA repair pathways.

bioRxiv · Feb 1, 2018Cell Biology