L. Ying

B cell receptor silencing reveals the origin of high-grade B cell lymphomas with MYC and BCL2 rearrangements

This paper shows that high-grade B cell lymphomas with MYC and BCL2 rearrangements originate from BCR-silenced follicular lymphoma cells that acquire IGL::MYC translocations, leading to resistance to CD79B-targeting therapy.

Therapeutic Peptide SS-31 Modulates Membrane Binding and Aggregation of Alpha-Synuclein and Restores Impaired Mitochondrial Function

This study shows SS-31 reduces alpha-synuclein membrane binding, aggregation, and mitochondrial dysfunction in neuroblastoma cells.

Modeling Mechanical Activation of Macrophages During Pulmonary Fibrogenesis for Targeted Anti-Fibrosis Therapy

This study models mechanical activation of macrophages in fibrotic lung tissue and shows pirfenidone inhibits this activation, offering a new mechanism for anti-fibrosis therapy.

Knockout of E-cadherin in adult mouse epithelium results in emphysema and airway disease

This study shows that loss of E-cadherin in adult mouse lung epithelium causes emphysema and airway disease, suggesting a causal role in COPD.

Myeloid lncRNA LOUP Mediates Opposing Regulatory Effects of RUNX1 and RUNX1-ETO in t(8;21) AML

The paper identifies the long noncoding RNA LOUP as a mediator of RUNX1 and RUNX1-ETO effects in t(8;21) AML, showing it promotes myeloid differentiation and inhibits cell growth by regulating PU.1 expression.

Virtual Mouse Brain Histology from Multi-contrast MRI via Deep Learning

This paper uses deep learning to estimate histological staining intensity from MRI signals, creating virtual histology maps of mouse brains with enhanced sensitivity and specificity.

Unsupervised graph-based learning predicts mutations that alter protein dynamics

The paper uses graph-based learning to predict mutations affecting protein dynamics, validated by FRET experiments on adenylate kinase.

The Salix SmSPR1 Involved in Light-Regulated Cell Expansion by Modulating Microtubule Arrangement

This study identifies SmSPR1's role in light-regulated cell expansion by modulating microtubule arrangement in Salix matsudana, showing its interaction with photomorphogenesis regulators.

NOD1 mediates non-canonical inflammasome processing of interleukin-18 in epithelial cells to Helicobacter pylori infection.

This study identifies NOD1 as a key regulator of IL-18 processing in epithelial cells during Helicobacter pylori infection, independent of canonical inflammasome proteins.