Author

A. E. Maclean

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Plant Biology· 3 Biochemistry· 2 Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:cell type annotation· 5 Organism:Arabidopsis· 4 Assay:proteomics· 4 Research Focus:differential expression· 3 Research Focus:protein folding & dynamics· 3 Research Focus:gene regulatory network inference· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

J. Balk· 5 shared I. Kruse· 2 shared L. Sheiner· 2 shared A. J. Meyer· 1 shared A. Moseler· 1 shared D. Liebsch· 1 shared E. A. Renaud· 1 shared E. L. Bastow· 1 shared

Activity by Year

2017-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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5 shared papersPlant Biology

J. Balk

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

The Toxoplasma gondii mitochondrial transporter ABCB7 is essential for cytosolic iron-sulfur cluster biogenesis and protein translation

A. E. Maclean, M. A. Sloan, E. A. Renaud, V. Demolombe, S. Besteiro, L. Sheiner

This study identifies and characterizes the Toxoplasma gondii ABCB7 homolog, showing its essential role in cytosolic iron-sulfur cluster biogenesis and protein translation.

bioRxiv · Mar 15, 2024 · PreprintMicrobiology

The Fe-S cluster assembly factors NFU4 and NFU5 are primarily required for protein lipoylation in mitochondria

J. Przybyla-Toscano, A. E. Maclean, M. Franceschetti, D. Liebsch, F. Vignols, O. Keech, N. Rouhier, J. Balk

This study identifies NFU4 and NFU5 as essential for mitochondrial protein lipoylation, with specific roles in lipoate biosynthesis for dehydrogenases.

bioRxiv · Sep 24, 2021 · PreprintPlant Biology

Complexome profile of Toxoplasma gondii mitochondria identifies a divergent cytochrome bc1 complex

A. E. Maclean, H. R. Bridges, M. F. Silva, S. Ding, J. Hirst, L. Sheiner

This study identifies new subunits of Toxoplasma gondii's mitochondrial complex III using complexome profiling, revealing their essential role in parasite survival and drug target potential.

PLOS Pathogens · Mar 2, 2021Peer-reviewedCell Biology

Branched-chain amino acid catabolism depends on GRXS15 through mitochondrial lipoyl cofactor homeostasis

A. Moseler, I. Kruse, A. E. Maclean, L. Pedroletti, S. Wagner, R. Wehler, K. Fischer-Schrader, G. Poschet, M. Wirtz, P. Dörmann, T. M. Hildebrandt, R. Hell, M. Schwarzländer, J. Balk, A. J. Meyer

The paper shows that GRXS15 deficiency disrupts mitochondrial lipoyl cofactor homeostasis, leading to metabolic defects in lipoyl cofactor-dependent dehydrogenase complexes, particularly affecting branched-chain amino acid catabolism.

bioRxiv · Feb 13, 2020 · PreprintPlant Biology

Pathogenic mutations in NUBPL affect complex I activity and cold tolerance in the yeast model Yarrowia lipolytica

A. E. Maclean, V. E. Kimonis, J. Balk

The paper investigates the effects of NUBPL mutations on complex I activity and cold tolerance in Yarrowia lipolytica by recreating amino acid substitutions and analyzing their impact on complex I assembly and function.

bioRxiv · Jun 4, 2018Biochemistry

Vacuolar iron stores gated by NRAMP3 and NRAMP4 are the primary source of iron in germinating seeds

E. L. Bastow, V. S. Garcia de la Torre, A. E. Maclean, R. T. Green, S. Merlot, S. Thomine, J. Balk

The paper shows that NRAMP3 and NRAMP4 are essential for mobilizing vacuolar iron stores during seed germination, and their absence triggers Fe deficiency responses affecting plastids but not mitochondria.

bioRxiv · Apr 24, 2018Plant Biology

Genetic dissection of cyclic pyranopterin monophosphate biosynthesis in plant mitochondria

I. Kruse, A. E. Maclean, L. Hill, J. Balk

This study identifies new mutants in Arabidopsis thaliana that affect molybdenum cofactor biosynthesis, revealing roles for ATM3 and CNX2 in cyclic pyranopterin monophosphate (cPMP) synthesis.

bioRxiv · Dec 14, 2017Biochemistry