Author

S. Besteiro

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 8

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Research Focus:host-pathogen & immune response· 4 Research Focus:cell type annotation· 3 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

A. Cerutti· 4 shared E. A. Renaud· 4 shared L. Berry· 3 shared Y. Bordat· 3 shared H. M. Nguyen· 2 shared S. Pamukcu· 2 shared V. Demolombe· 2 shared V. Rofidal· 2 shared

Activity by Year

2017-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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4 shared papersMicrobiology

A. Cerutti

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Author profile →

8 papers

Recent·Most cited

HCF101 is a novel component of the CIA cytosolic iron-sulfur synthesis pathway in the human pathogen Toxoplasma gondii

E. A. Renaud, A. J. Maupin, L. Berry, J. Bals, Y. Bordat, V. Demolombe, V. Rofidal, F. Vignols, S. Besteiro

This paper identifies HCF101 as a novel component of the cytosolic Fe-S assembly pathway in Toxoplasma gondii, essential for parasite survival and a potential drug target.

bioRxiv · May 1, 2024Microbiology

The Toxoplasma gondii mitochondrial transporter ABCB7 is essential for cytosolic iron-sulfur cluster biogenesis and protein translation

A. E. Maclean, M. A. Sloan, E. A. Renaud, V. Demolombe, S. Besteiro, L. Sheiner

This study identifies and characterizes the Toxoplasma gondii ABCB7 homolog, showing its essential role in cytosolic iron-sulfur cluster biogenesis and protein translation.

bioRxiv · Mar 15, 2024 · PreprintMicrobiology

Iron depletion has different consequences on the growth and survival of Toxoplasma gondii strains

E. A. Renaud, A. J. M. Maupin, Y. Bordat, A. Graindorge, L. Berry, S. Besteiro

This study examines how iron depletion affects different Toxoplasma gondii strains, finding that acute strains are more sensitive than cystogenic strains.

bioRxiv · Dec 21, 2023Microbiology

The apicoplast is important for the viability and persistence of Toxoplasma gondii bradyzoites

S. G. Sanchez, E. Bassot, A. Cerutti, H. M. Nguyen, A. Aïda, N. Blanchard, S. Besteiro

This study shows that targeting the apicoplast in Toxoplasma gondii bradyzoites reduces their viability, suggesting it as a potential therapeutic target for chronic infections.

bioRxiv · Jan 13, 2023Microbiology

Disrupting the plastid-hosted iron-sulfur cluster biogenesis pathway in Toxoplasma gondii has pleiotropic effects irreversibly impacting parasite viability

E. A. Renaud, S. Pamukcu, A. Cerutti, L. Berry, C. Lemaire-Vieille, Y. Yamaryo-Botte, C. Y. Botte, S. Besteiro

This study shows that disrupting the SUF iron-sulfur cluster pathway in Toxoplasma gondii severely impairs parasite growth and viability through multiple metabolic and functional defects.

bioRxiv · Mar 18, 2022Microbiology

Toxoplasma TgATG9 is critical for autophagy and long-term persistence in tissue cysts

D. Smith, G. Kannan, I. Coppens, F. Wang, H. M. Nugyen, A. Cerutti, T. L. B. Schultz, P. Rimple, M. Di Cristina, S. Besteiro, V. B. Carruthers

This study shows that TgATG9 is essential for autophagy and long-term survival of Toxoplasma gondii bradyzoites in tissue cysts.

eLife · Apr 27, 2021Peer-reviewedMicrobiology

Differential contribution of two organelles of endosymbiotic origin to iron-sulfur cluster synthesis and overall fitness in Toxoplasma

S. Pamukcu, A. Cerutti, Y. Bordat, S. Hem, V. Rofidal, S. Besteiro

This study compares the effects of disrupting two Fe-S cluster synthesis pathways in Toxoplasma gondii, showing that plastidic disruption leads to organelle loss and death, while mitochondrial disruption triggers stress resistance.

bioRxiv · Jan 28, 2021Microbiology

Characterisation of two Toxoplasma PROPPINs homologous to Atg18/WIPI suggests they have evolved distinct specialised functions

H. M. Nguyen, S. Liu, W. Daher, F. Tan, S. Besteiro

This study characterizes two Toxoplasma PROPPINs homologous to ATG18/WIPI, revealing distinct specialized functions in autophagy-related processes.

bioRxiv · Dec 18, 2017Microbiology