L. Sheiner

The Toxoplasma gondii mitochondrial transporter ABCB7 is essential for cytosolic iron-sulfur cluster biogenesis and protein translation

This study identifies and characterizes the Toxoplasma gondii ABCB7 homolog, showing its essential role in cytosolic iron-sulfur cluster biogenesis and protein translation.

Plasmodium falciparum mitochondrial complex III, the target of atovaquone, is essential for progression to the transmissible sexual stages.

This study shows that Plasmodium falciparum complex III is essential for asexual stage survival and gametocyte maturation, supporting its role as a drug target.

Pyrimidine salvage in Toxoplasma gondii as a target for new treatment

This paper identifies TgUUT1 as a key pyrimidine salvage transporter in Toxoplasma gondii and demonstrates that 5F-uracil derivatives are potent antiparasitic agents with efficacy comparable to sulfadiazine.

Complexome profile of Toxoplasma gondii mitochondria identifies a divergent cytochrome bc1 complex

This study identifies new subunits of Toxoplasma gondii's mitochondrial complex III using complexome profiling, revealing their essential role in parasite survival and drug target potential.

Depletion of voltage-dependent anion channel (VDAC) of Toxoplasma gondii affects multiple mitochondrial functions, but not calcium signalling.

This study shows that VDAC in Toxoplasma gondii is essential for mitochondrial protein import and metabolite transfer but does not regulate calcium signaling.

Lipoic acid biosynthesis is essential for Plasmodium falciparum transmission and influences redox response and carbon metabolism of parasite asexual blood stages

In silico screen identifies a new Toxoplasma gondii mitochondrial ribosomal protein essential for mitochondrial translation

The paper identifies a new Toxoplasma gondii mitochondrial ribosomal protein essential for mitochondrial translation through in silico screening and experimental validation.