Author

G. Poschet

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Plant Biology· 3 Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Assay:metabolomics· 5 Organism:human· 4 Assay:proteomics· 4 Organism:Arabidopsis· 3 Research Focus:benchmarking· 3 Research Focus:cell type annotation· 3 Approach:benchmark study· 1

Frequent Co-Authors

R. Hell· 6 shared A. J. Meyer· 3 shared A. Moseler· 3 shared H. M. Gegner· 3 shared M. Wirtz· 3 shared S. Wagner· 3 shared A. Dugourd· 2 shared C. Andresen· 2 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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Curved chords = mutual co-authorship

6 shared papersPlant Biology

R. Hell

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

A single-sample workflow for joint metabolomic and proteomic analysis of clinical specimens

H. Gegner, T. Naake, K. Aljakouch, A. Dugourd, G. Kliewer, T. Mueller, D. Schilling, M. A. Schneider, N. Kunze, T. G. P. Gruenewald, R. Hell, J. Saez-Rodriguez, W. Huber, G. Poschet, J. Krijgsveld

The paper introduces a single-sample workflow, MTBE-SP3, for simultaneous proteomic and metabolomic analysis, showing it reduces technical variation and enables consistent results across biological matrices.

bioRxiv · Nov 7, 2023 · PreprintCancer Biology

Altered iron-sulfur cluster transfer in Arabidopsis mitochondria reveals lipoyl synthase as a Janus-faced enzyme that generates toxic sulfide

L. Pedroletti, A. Moseler, S. Timm, G. Poschet, M. Homagk, J. X. The, S. Wagner, M. Wirtz, R. Hell, A. J. Meyer

The paper shows that altered iron-sulfur cluster transfer in Arabidopsis mitochondria leads to toxic sulfide release by lipoyl synthase, affecting plant growth and sulfide homeostasis.

bioRxiv · Aug 30, 2023 · PreprintPlant Biology

Pre-analytical processing of plasma and serum samples for combined proteome and metabolome analysis

H. M. Gegner, T. Naake, A. Dugourd, T. Mueller, F. Czernilofsky, G. Kliewer, E. Jaeger, B. Helm, N. Kunze-Rohrbach, U. Klingmueller, C. Hopf, C. Mueller-Tidow, S. Dietrich, J. Saez-Rodriguez, W. Huber, , J. Krijgsveld

This study evaluates pre-analytical factors affecting plasma and serum proteome and metabolome stability, recommending standardized protocols for clinical use.

bioRxiv · Apr 26, 2022Biochemistry

Deep metabolic profiling assessment of tissue extraction protocols for three model organisms

H. M. Gegner, N. Mechtel, E. Heidenreich, A. Wirth, F. G. Cortizo, K. Bennewitz, T. Fleming, C. Andresen, M. Freichel, A. A. Teleman, J. Kroll, R. Hell, G. Poschet

The paper evaluates extraction protocols for metabolomic profiling in three model organisms, finding a protocol that balances reproducibility and metabolite detection across tissues.

bioRxiv · Dec 16, 2021Biochemistry

Comparison of extraction methods for intracellular metabolomics

C. Andresen, T. Boch, H. M. Gegner, N. Mechtel, A. Narr, E. Birgin, E. Rasbach, N. N. Rahbari, A. Trumpp, G. Poschet, D. Huebschmann

The paper compares ten metabolomics extraction protocols across four human sample types to identify the most effective method for quantifying 630 metabolites.

bioRxiv · Dec 15, 2021 · PreprintBiochemistry

MYCN mediates cysteine addiction and sensitizes to ferroptosis

H. Alborzinia, A. F. Florez, S. Gogolin, L. M. Brueckner, C. Shao, M. Gartlgruber, M. Nadler Holly, M. Ziehm, F. Paul, S. Steinhauser, E. Bell, M. Shaikhkarami, S. Hartlieb, D. Dreidax, E. M. Hess, , F. Westermann

This study shows MYCN promotes cysteine addiction and ferroptosis resistance in neuroblastoma, identifying therapeutic targets for ferroptosis induction.

bioRxiv · Aug 10, 2021 · PreprintCancer Biology

Branched-chain amino acid catabolism depends on GRXS15 through mitochondrial lipoyl cofactor homeostasis

A. Moseler, I. Kruse, A. E. Maclean, L. Pedroletti, S. Wagner, R. Wehler, K. Fischer-Schrader, G. Poschet, M. Wirtz, P. Dörmann, T. M. Hildebrandt, R. Hell, M. Schwarzländer, J. Balk, A. J. Meyer

The paper shows that GRXS15 deficiency disrupts mitochondrial lipoyl cofactor homeostasis, leading to metabolic defects in lipoyl cofactor-dependent dehydrogenase complexes, particularly affecting branched-chain amino acid catabolism.

bioRxiv · Feb 13, 2020 · PreprintPlant Biology

Redox-mediated Kick-Start of Mitochondrial Energy Metabolism drives Resource-efficient Seed Germination

T. Nietzel, J. Mostertz, C. Ruberti, S. Wagner, A. Moseler, P. Fuchs, S. J. Mueller-Schuessele, A. Benamar, G. Poschet, M. Buettner, G. Nee, I. M. Moller, C. H. Lillig, D. Macherel, I. Finkemeier, , M. Schwarzlaender

The paper identifies redox-mediated activation of mitochondrial energy metabolism as critical for efficient seed germination in Arabidopsis.

Proceedings of the National Academy of Sciences · Dec 23, 2019Peer-reviewedPlant Biology