Author

A. F. L. Hurlstone

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1 Organism:zebrafish· 1

Frequent Co-Authors

D. J. Wilcock· 2 shared M. P. Smith· 2 shared P. Lorigan· 2 shared A. D. Southam· 1 shared A. Jankevics· 1 shared A. P. Badrock· 1 shared B. A. Telfer· 1 shared C. Ceol· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersCancer Biology

D. J. Wilcock

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2 papers

Recent·Most cited

PARP14 inhibition restores PD-1 immune checkpoint inhibitor response following IFNγ-driven adaptive resistance

C. W. Wong, C. Evangelou, K. N. Sefton, R. Leshem, K. Sergiou, M. L. Fernandez Carro, E. Uzuner, H. Mole, B. A. Telfer, D. J. Wilcock, M. P. Smith, K. Kunii, N. R. Perl, P. Lorigan, K. J. Williams, , A. F. L. Hurlstone

This study shows that PARP14 inhibition restores PD-1 checkpoint inhibitor response in IFNγ-resistant tumors by increasing T cell infiltration and reducing regulatory T cells.

Nature Communications · Sep 26, 2023Peer-reviewedCancer Biology

DGAT1 is a lipid metabolism oncoprotein that enables cancer cells to accumulate fatty acid while avoiding lipotoxicity

D. J. Wilcock, A. P. Badrock, R. Owen, M. Guerin, A. D. Southam, H. Johnston, S. Ogden, P. Fullwood, J. Watson, H. Ferguson, J. Haworth, D. A. Richardson, G. R. Lloyd, A. Jankevics, W. B. Dunn, , A. F. L. Hurlstone

This study identifies DGAT1 as an oncoprotein that enables cancer cells to accumulate fatty acids while avoiding lipotoxicity, promoting melanoma formation.

bioRxiv · Jun 23, 2020 · PreprintCancer Biology