An Engineered 3D Co-culture Model of Primary Macrophages and Patient-Derived Tumour Cells to Explore Cellular Responses in the Graded Hypoxic Microenvironment of Pancreatic Cancer
I. L. Co, C. Yu, S. Lamorte, M. T. Ciudad, N. Landon-Brace, J. L. Cadavid, Z. Xia, A. Fomina, M. Nurse, T. L. McGaha, K. R. Campbell, A. P. McGuigan
This paper develops a 3D co-culture model of macrophages and PDAC organoids to study hypoxia-driven cellular interactions and their impact on chemoresistance and immune responses.
bioRxiv · Jul 13, 2023 · PreprintBioengineering