Author

E. Koncina

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Biochemistry· 1 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cancer & tumor microenvironment· 3 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Organism:human· 2 Assay:metabolomics· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

E. Letellier· 5 shared J. Meiser· 3 shared C. Jaeger· 2 shared D. Brenner· 2 shared G. Dittmar· 2 shared L. Neises· 2 shared L. Soriano-Baguet· 2 shared M. Schmoetten· 2 shared

Activity by Year

2022-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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5 shared papersCancer Biology

E. Letellier

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

The gut microbiome-linked long chain fatty acid stearate suppresses colorectal cancer

M. Tsenkova, M. Brauer, V. Pozdeev, M. Kasakin, S. B. Busi, M. Schmoetten, D. Cheung, M. Meyers, F. Rodriguez, A. Gaigneaux, E. Koncina, C. Gilson, L. Schlicker, D. Herebian, M. Schmitz, , E. Letellier

This study shows that the ketogenic diet reduces colorectal tumors in mice by altering the gut microbiome to increase stearic acid, which suppresses cancer cell growth and immune responses.

bioRxiv · Dec 7, 2023 · PreprintCancer Biology

A Th17 cell-intrinsic glutathione/mitochondrial-IL-22 axis protects against intestinal inflammation

L. Bonetti, V. Horkova, J. Longworth, L. Guerra, H. Kurniawan, D. G. Franchina, L. Soriano-Baguet, M. Grusdat, S. Spath, E. Koncina, A. Ewen, C. Binsfeld, C. Verscheuren, J.-J. Gerardy, T. Kobayashi, , D. Brenner

This study identifies a Th17 cell-intrinsic glutathione/mitochondrial-IL-22 axis that protects against intestinal inflammation by maintaining barrier integrity and preventing mortality from C. rodentium infection.

bioRxiv · Jul 6, 2023Immunology

Metabolic plasticity of serine metabolism is crucial for cGAS/STING-signalling and innate immune response to viral infections in the gut

B. Becker, F. Wottawa, M. Bakr, E. Koncina, L. Mayr, J. Kugler, G. Yang, S. J. Windross, L. Neises, N. Mishra, D. Harris, F. Tran, L. Welz, J. Schwaerzler, Z. Banki, , K. Aden

The paper identifies metabolic changes in serine metabolism linked to cGAS/STING-signalling and immune response in gut inflammation.

bioRxiv · May 17, 2022 · PreprintCell Biology

Mitochondria preserve an autarkic one-carbon cycle to confer growth-independent cancer cell migration and metastasis

N. Kiweler, C. Delbrouck, V. I. Pozdeev, L. Neises, L. Soriano-Baguet, K. Eiden, F. Xian, M. Benzarti, L. Haase, E. Koncina, M. Schmoetten, C. Jaeger, M. Z. Noman, A. Vazquez, B. Janji, , J. Meiser

This study identifies mitochondrial one-carbon metabolism as a key driver of cancer cell migration and metastasis independent of proliferation.

Nature Communications · May 16, 2022Peer-reviewedCancer Biology

Highly multiplexed targeted plasma proteomics quantifies several hundred blood proteins in serum from colorectal carcinoma patients

A. Lesur, F. Bernardin, E. Koncina, E. Letellier, G. Kruppa, P.-O. Schmit, G. Dittmar

This study uses targeted plasma proteomics to quantify 565 blood proteins in CRC patients and identifies 16 differentially regulated proteins correlated with mRNA expression in tumor samples.

bioRxiv · Apr 1, 2022 · PreprintBiochemistry