Author

J. Longworth

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

A. Badkas· 1 shared A. Ewen· 1 shared A. Gaigneaux· 1 shared A. Hemedan· 1 shared A. Muller· 1 shared A. Sinha· 1 shared A. Thakur· 1 shared A. Waisman· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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1 shared paperCancer Biology

A. Badkas

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

A Th17 cell-intrinsic glutathione/mitochondrial-IL-22 axis protects against intestinal inflammation

L. Bonetti, V. Horkova, J. Longworth, L. Guerra, H. Kurniawan, D. G. Franchina, L. Soriano-Baguet, M. Grusdat, S. Spath, E. Koncina, A. Ewen, C. Binsfeld, C. Verscheuren, J.-J. Gerardy, T. Kobayashi, , D. Brenner

This study identifies a Th17 cell-intrinsic glutathione/mitochondrial-IL-22 axis that protects against intestinal inflammation by maintaining barrier integrity and preventing mortality from C. rodentium infection.

bioRxiv · Jul 6, 2023Immunology

A multi-omics integrative approach unravels novel genes and pathways associated with senescence escape after targeted therapy in NRAS mutant melanoma

V. Gureghian, H. Herbst, I. Kozar, K. Mihajlovic, N. Malod-Dognin, G. Ceddia, C. Angeli, C. Margue, T. Randic, D. Philippidou, M. Tetsi Nomigni, A. Hemedan, L.-C. Tranchevent, J. Longworth, M. Bauer, , S. Kreis

This study identifies genes and pathways involved in senescence escape in NRAS mutant melanoma using multi-omics approaches.

bioRxiv · Feb 13, 2023Cancer Biology

Rub1/NEDD8, a ubiquitin-like modifier, is also a ubiquitin modifier

S. Zerath Gurevich, A. Sinha, J. Longworth, R. K. Singh, B. E. Lemma, A. Thakur, O. Popp, D. Kornitzer, N. Reis, M. Scheffner, G. Dittmar, E. Pick, D. Fushman, M. H. Glickman

This paper shows that a single amino acid swap at position 72 can switch the substrate specificity of Rub1/NEDD8 and ubiquitin, revealing their distinct roles in cellular modification pathways.

bioRxiv · Jun 18, 2020 · PreprintBiochemistry