Microbiome-specific T follicular helper cells drive tertiary lymphoid structures and anti-tumor immunity against colorectal cancer.
A. E. Overacre-Delgoffe, A. R. Cillo, H. J. Bumgarner, A. H. Burr, J. T. Tometich, A. Bhattacharjee, T. C. Bruno, D. A. Vignali, T. Hand
The paper shows that introducing an immunogenic commensal bacteria modifies the microbiome to enhance anti-tumor immunity in colorectal cancer by promoting tertiary lymphoid structures and T follicular helper cell activity.
bioRxiv · Jan 27, 2021 · PreprintImmunology