T. C. Bruno

All-trans retinoic acid induces durable tumor immunity in IDH-mutant gliomas by rescuing transcriptional repression of the CRBP1-retinoic acid axis

This study shows that all-trans retinoic acid (ATRA) improves immune response in IDH-mutant gliomas by restoring the RA pathway, leading to tumor regression in mouse models and a clinical trial for human patients.

Antibodies targeting conserved non-canonical antigens and endemic coronaviruses associate with favorable outcomes in severe COVID-19

The paper identifies antibody responses against non-canonical and endemic coronavirus antigens as predictors of favorable outcomes in severe COVID-19.

Bifurcated monocyte states are predictive of mortality in severe COVID-19

The paper identifies bifurcated monocyte states in severe COVID-19 patients that predict mortality, with distinct cytokine and interferon gene modules associated with survival or death.

Microbiome-specific T follicular helper cells drive tertiary lymphoid structures and anti-tumor immunity against colorectal cancer.

The paper shows that introducing an immunogenic commensal bacteria modifies the microbiome to enhance anti-tumor immunity in colorectal cancer by promoting tertiary lymphoid structures and T follicular helper cell activity.

Divergent cancer etiologies drive distinct B cell signatures and tertiary lymphoid structures

This study identifies distinct B cell signatures and tertiary lymphoid structures in HPV+ and HPV- HNSCC, highlighting their role in antitumor immunity.

Systemic immune dysfunction in cancer patients driven by IL6 and IL8 induction of an inhibitory receptor module in peripheral CD8+ T cells

This study identifies a systemic immune dysfunction in cancer patients driven by IL6 and IL8, leading to CD8+ T cell dysfunction and poor prognosis.