C. W. Marshall

Bacillus subtilis maintains antibiofilm activity against Staphylococcus aureus following adaptive laboratory evolution

This study shows that long-term exposure to Bacillus subtilis 6D1 metabolites reduces S. aureus biofilm fitness and increases antibiotic sensitivity, while maintaining antibiofilm activity.

Plant growth promoting activity of bacteria isolated from Asian rice (Oryza sativa L.) are plant subspecies dependent

The paper investigates plant growth promoting bacteria isolated from Asian rice subspecies, finding that some bacteria enhance JAPONICA growth but not INDICA.

Excess dietary sugar impairs colonic epithelial regeneration in response to damage.

This study shows that high sugar diets impair colonic epithelial regeneration by altering metabolic pathways in intestinal stem cells.

Immunosuppression broadens evolutionary pathways to treatment failure during Acinetobacter baumannii pneumonia

This study shows that immunosuppression promotes antibiotic resistance evolution in Acinetobacter baumannii pneumonia by enabling persistence mutations that cause treatment failure without clinical resistance.

Rampant prophage movement among transient competitors drives rapid adaptation during infection

The paper shows prophage-mediated active lysogeny drives rapid, parallel adaptations in bacterial infections by disrupting global regulator genes, increasing cyclic-di-GMP and biofilm production.

Experimental evolution to identify undescribed mechanisms of resistance to a novel cationic peptide antibiotic

This study uses experimental evolution and whole genome sequencing to identify genetic mechanisms of resistance to the cationic peptide antibiotic WLBU2 in Pseudomonas aeruginosa.

Evolution and adaptation of Pseudomonas aeruginosa in the paranasal sinuses of people with cystic fibrosis

This study identifies three evolutionary genetic routes of Pseudomonas aeruginosa adaptation in the sinuses of people with cystic fibrosis, suggesting sinuses may be an early site of pathoadaptation before lung infections.

The roles of history, chance, and natural selection in the evolution of antibiotic resistance

This study quantifies how history, chance, and selection influence the evolution of antibiotic resistance in Acinetobacter baumannii through controlled experiments.

Host adaptations in the fixLJ pathway of the Burkholderia cepacia complex increase virulence

This study shows that evolved variants of the fixLJ pathway in BCC species enhance virulence in host models but reduce survival in soil.

Parallel evolution of tobramycin resistance across species and environments

This study identifies parallel mutations in fusA1 and ptsP across two bacterial species under tobramycin selection, showing predictable resistance mechanisms despite environmental and genetic differences.

Evolutionary pathways to antibiotic resistance are dependent upon environmental structure and bacterial lifestyle

This study shows that biofilm lifestyle in Acinetobacter baumannii leads to different genetic pathways and fitness trade-offs in antibiotic resistance evolution compared to planktonic growth.