Author

A. H. Newman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Organism:Drosophila· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Approach:mechanistic / dynamical model· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

A. Bonifazi· 2 shared K. H. Lee· 2 shared L. Shi· 2 shared A. El-Kasaby· 1 shared A. Kasture· 1 shared A. Semeano· 1 shared D. A. Guthrie· 1 shared F. O. Battiti· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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2 shared papersPharmacology & Toxicology

A. Bonifazi

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3 papers

Recent·Most cited

A subtle modification of modafinil-based DAT inhibitors changes conformational preference

K. H. Lee, G. A. Camacho-Hernandez, A. H. Newman, L. Shi

The paper investigates how a subtle structural change in modafinil analogs affects their binding to the dopamine transporter, revealing conformational differences between sulfoxide and sulfide substitutions.

bioRxiv · Mar 6, 2024Biophysics

Linkers in bitopic agonists shape bias profile among transducers for the dopamine D2 and D3 receptors

A. Semeano, R. Garland, A. Bonifazi, K. H. Lee, J. Famiglietti, W. Zhang, Y. J. Jo, F. O. Battiti, L. Shi, A. H. Newman, H. Yano

The paper analyzes bitopic ligands for dopamine D2 and D3 receptors, showing that linker structure and stereochemistry significantly influence transducer bias profiles.

bioRxiv · Jan 7, 2024Pharmacology & Toxicology

A tropane-based ibogaine analog rescues folding-deficient SERT and DAT

S. Bhat, D. A. Guthrie, A. Kasture, A. El-Kasaby, J. Cao, A. Bonifazi, T. Ku, T. Ku, J. B. Giancola, T. Hummel, M. Freissmuth, A. H. Newman

The paper identifies a tropane-based ibogaine analog that rescues folding-deficient SERT and DAT mutants in vitro and in vivo.

bioRxiv · Jul 14, 2020Pharmacology & Toxicology