Author

N. Sinnott-Armstrong

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1 Evolutionary Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:statistical model· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Assay:GWAS summary statistics· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

J. K. Pritchard· 2 shared A. H. Shain· 1 shared A. Harpak· 1 shared A. Krishnan· 1 shared A. M. Joergensen· 1 shared A. Subramaniam· 1 shared A. Zaman· 1 shared C. Curtis· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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2 shared papersCancer Biology

J. K. Pritchard

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Author profile →

4 papers

Recent·Most cited

SIRPα controls CD47-dependent platelet clearance in mice and humans

M. Shoham, Y. Y. Yiu, P. Hansen, A. Subramaniam, M. Broberg, E. Gars, T. Raveh, FinnGen, I. L. Weissman, N. Sinnott-Armstrong, A. Krishnan, H. Ollila, M. C. Tal

This study shows that the CD47-SIRP axis regulates platelet homeostasis and that blocking this interaction affects platelet levels in mice and humans.

bioRxiv · Dec 9, 2023 · PreprintImmunology

Convergent mutations in tissue-specific regulatory regions reveal novel cancer drivers

N. Sinnott-Armstrong, J. A. Seoane, R. Sallari, J. K. Pritchard, C. Curtis, M. P. Snyder

This study identifies non-coding cancer drivers by analyzing convergent mutations in tissue-specific regulatory regions across multiple cancer types, finding several genes associated with survival.

bioRxiv · Aug 21, 2020 · PreprintCancer Biology

Global analysis of epigenetic heterogeneity identifies divergent drivers of esophageal squamous cell carcinoma

W. CAO, H. Lee, W. Wu, A. Zaman, S. McCorkle, M. Yan, J. Chen, Q. Xing, N. Sinnott-Armstrong, H. Xu, M. R. Sailani, W. Tang, Y. Cui, J. Liu, H. Guan, , T. G. Bivona

The paper identifies epigenetic drivers of esophageal squamous cell carcinoma through multi-omics analysis, revealing hypomethylation patterns and non-canonical WNT signaling activation.

bioRxiv · May 18, 2019 · PreprintCell Biology

Reduced signal for polygenic adaptation of height in UK Biobank

J. J. Berg, A. Harpak, N. Sinnott-Armstrong, A. M. Joergensen, H. Mostafavi, Y. Field, E. A. Boyle, X. Zhang, F. Racimo, J. K. Pritchard, G. Coop

The paper analyzes polygenic height scores from UK Biobank and finds reduced signals of selection compared to previous studies, suggesting potential issues with population stratification correction.

bioRxiv · Dec 10, 2018Evolutionary Biology