Author

J. K. Pritchard

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 3 Cell Biology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 4 Organism:human· 3 Assay:whole-genome sequencing· 3 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Organism:chicken / avian· 1

Frequent Co-Authors

H. Mostafavi· 2 shared N. Sinnott-Armstrong· 2 shared A. Harpak· 1 shared A. L. Fortier· 1 shared A. M. Joergensen· 1 shared A. P. Turkewitz· 1 shared C. Curtis· 1 shared C. Kontur· 1 shared

Activity by Year

2017-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersEvolutionary Biology

H. Mostafavi

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Author profile →

6 papers

Recent·Most cited

Scaling the Discrete-time Wright Fisher model to biobank-scale datasets

J. P. Spence, T. Zeng, H. Mostafavi, J. K. Pritchard

This paper introduces an algorithm to scale the Discrete-Time Wright Fisher model to large datasets, enabling efficient and accurate population genetic inference at biobank scale.

bioRxiv · May 19, 2023Evolutionary Biology

Ancient Trans-Species Polymorphism at the Major Histocompatibility Complex in Primates

A. L. Fortier, J. K. Pritchard

The paper investigates ancient trans-species polymorphism at MHC genes in primates, finding strong support for ancient TSP in 7 of 10 classical genes and rapid evolution in peptide-binding domains linked to disease associations.

bioRxiv · Jun 28, 2022Evolutionary Biology

A genome-wide genetic screen uncovers novel determinants of human pigmentation

V. K. Bajpai, T. Swigut, J. Mohammed, J. Tycko, S. Naqvi, M. Arreola, T. Kim, N. Arora, J. K. Pritchard, M. C. Bassik, J. Wyscoka

A genome-wide CRISPR-Cas9 screen identifies novel genes regulating melanogenesis, many upregulated in dark skin melanocytes and associated with skin color variation.

bioRxiv · Sep 29, 2021 · PreprintCell Biology

Convergent mutations in tissue-specific regulatory regions reveal novel cancer drivers

N. Sinnott-Armstrong, J. A. Seoane, R. Sallari, J. K. Pritchard, C. Curtis, M. P. Snyder

This study identifies non-coding cancer drivers by analyzing convergent mutations in tissue-specific regulatory regions across multiple cancer types, finding several genes associated with survival.

bioRxiv · Aug 21, 2020 · PreprintCancer Biology

Reduced signal for polygenic adaptation of height in UK Biobank

J. J. Berg, A. Harpak, N. Sinnott-Armstrong, A. M. Joergensen, H. Mostafavi, Y. Field, E. A. Boyle, X. Zhang, F. Racimo, J. K. Pritchard, G. Coop

The paper analyzes polygenic height scores from UK Biobank and finds reduced signals of selection compared to previous studies, suggesting potential issues with population stratification correction.

bioRxiv · Dec 10, 2018Evolutionary Biology

An evolutionary switch in the specificity of an endosomal CORVET tether underlies formation of regulated secretory vesicles in the ciliate Tetrahymena thermophila

D. Sparvoli, E. Richardson, H. Osakada, X. Lan, M. Iwamoto, G. R. Bowman, C. Kontur, W. A. Bourland, D. H. Lynn, J. K. Pritchard, T. Haraguchi, J. B. Dacks, A. P. Turkewitz

The paper identifies an evolutionary switch in the specificity of a CORVET tether in Tetrahymena thermophila that enables the formation of regulated secretory vesicles called mucocysts.

bioRxiv · Oct 27, 2017Cell Biology