Author

A. Hassinen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1

Frequent Co-Authors

A. Bugai· 1 shared A. Manninen· 1 shared A. Samoylenko· 1 shared C. Friedel· 1 shared D. Mennerich· 1 shared E. Biterova· 1 shared E. Y. Dimova· 1 shared I. Miinalainen· 1 shared

Activity by Year

2018-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperBiochemistry

A. Bugai

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Author profile →

2 papers

Recent·Most cited

P-TEFb promotes cell survival upon p53 activation by suppressing intrinsic apoptosis pathway

Z. Wang, M. Macakova, A. Bugai, S. G. Kuznetsov, A. Hassinen, T. Lenasi, S. Potdar, C. Friedel, M. Barboric

This study identifies P-TEFb as a factor that promotes cell survival by suppressing the intrinsic apoptosis pathway when p53 is activated, suggesting its potential as a therapeutic target in combination with apoptosis inducers.

bioRxiv · May 29, 2022Biochemistry

The pro-oncogenic adaptor CIN85 inhibits hypoxia-inducible factor prolyl hydroxylase-2

N. Kozlova, D. Mennerich, A. Samoylenko, E. Y. Dimova, P. Koivunen, E. Biterova, K. Richter, A. Hassinen, S. Kellokumpu, A. Manninen, I. Miinalainen, V. Glumoff, L. Ruddock, L. Drobot, T. Kietzmann

This study identifies CIN85 as a novel binding partner of PHD2, showing it inhibits PHD2 activity and HIF degradation, promoting tumor growth in mice.

bioRxiv · Nov 20, 2018Biochemistry