T. Kietzmann

The E3 ubiquitin ligase DTX3L and the deubiquitinase USP28 fine-tune DNA double strand repair through mutual regulation of their protein levels

This paper identifies a regulatory feedback loop between DTX3L and USP28 that modulates DNA double-strand break repair by controlling protein levels and repair pathway efficiency.

Pan-cancer scale screening reveals NRF2 associated immunoevasive characteristics in non-small cell lung cancer and squamous malignancies

This paper identifies NRF2-associated immunoevasive features in NSCLC and squamous cancers, linking NRF2 activity to immune-cold phenotypes and potential biomarkers for immune checkpoint response.

Transcriptomic and Proteomic analysis of clear cell foci (CCF) in the human non-cirrhotic liver identifies several differentially expressed genes and proteins with functions in cancer cell biology and glycogen metabolism.

The paper identifies differentially expressed genes and proteins in liver clear cell foci (CCF) and finds that reduced expression of STBD1 and USP28 is unlikely to explain glycogen overload.

The pro-oncogenic adaptor CIN85 inhibits hypoxia-inducible factor prolyl hydroxylase-2

This study identifies CIN85 as a novel binding partner of PHD2, showing it inhibits PHD2 activity and HIF degradation, promoting tumor growth in mice.