K. Richter

Restraining Wnt activation and intestinal tumorigenesis by a Rab35 dependent GTPase relay

This study identifies Rab35 as a tumor suppressor that modulates Wnt signaling through a GTPase relay, highlighting its role in restraining intestinal tumorigenesis.

Early body weight gain in TALLYHO/JngJ mice predicts adult diabetic phenotype, mimicking childhood obesity

The paper identifies weaning body weight as a key predictor of adult diabetes in TALLYHO/JngJ mice, highlighting its relevance to childhood obesity research.

Antibiotics at Clinical Concentrations Show Limited Effectivity Against Acute and Chronic Intracellular S. aureus Infections in Osteocytes

This study evaluates the effectiveness of antibiotics against intracellular S. aureus infections in osteocytes, finding limited efficacy even at high concentrations.

Human Th17- and IgG3-associated autoimmunity induced by a translocating gut pathobiont

This study shows that the gut pathobiont Enterococcus gallinarum induces human Th17 and IgG3 autoantibody responses linked to disease activity in autoimmune patients.

Culture of Saos-2 cells under hypoxic conditions stimulates rapid differentiation to an osteocyte-like stage

This study shows that culturing Saos-2 cells under hypoxic conditions accelerates their differentiation into osteocyte-like cells within 14 days.

Lipid Droplets Fuel Small Extracellular Vesicle Biogenesis

This study shows that lipid droplets are linked to small extracellular vesicle biogenesis and that manipulating lipid droplets can affect sEV secretion and cargo.

Genomic landscapes of canine splenic angiosarcoma (hemangiosarcoma) contain extensive heterogeneity within and between patients

This study examines genomic heterogeneity in canine splenic hemangiosarcoma, identifying driver mutations and intratumoral diversity across multiple regions.

PFN2 and NAA80 cooperate to efficiently acetylate the N-terminus of actin

The paper identifies PFN2 as a specific regulator of NAA80, enhancing its catalytic activity and promoting actin N-terminal acetylation.

The pro-oncogenic adaptor CIN85 inhibits hypoxia-inducible factor prolyl hydroxylase-2

This study identifies CIN85 as a novel binding partner of PHD2, showing it inhibits PHD2 activity and HIF degradation, promoting tumor growth in mice.