A. Hilfinger

Noise properties of adaptation-conferring biochemical control modules

This study analyzes the noise properties of antithetic integral feedback (AIF) modules, showing that while perfect adaptation increases stochastic fluctuations, minor deviations can suppress noise with energetic cost.

Measuring prion propagation in single bacteria elucidates mechanism of loss

The paper investigates prion propagation in single bacterial cells, finding that prions are lost through random partitioning during division and that a stochastic model recapitulates observed properties.

Quantifying metal ion specificity of the nickel-binding protein CcNikZ-II from Clostridium carboxidivorans in the presence of competing metal ions

The paper quantifies how the nickel-binding protein CcNikZ-II from Clostridium carboxidivorans binds different metal ions in the presence of competitors using a fluorescence quenching method and kinetic models.

Quantifying biochemical reaction rates from static population variability within complex networks

The paper demonstrates how to infer biochemical reaction rates from static population variability data using incompletely specified mechanistic models.

Cell size homeostasis is maintained by a circuitry involving a CDK4-determined target size that programs the cell size-dependent activation of p38

The paper identifies CDK4 as a regulator of cell size target size, distinct from growth-promoting pathways, and proposes a model linking mTORC1, p38, and CDK4 in cell size homeostasis.