R. Kafri

CDK-4 regulates nucleolar size and metabolism at the cost of late life fitness in C. elegans

This study shows that CDK-4 in C. elegans regulates nucleolar size and metabolism, leading to improved early life thermotolerance but reduced longevity.

Oversized cells activate global proteasome-mediated protein degradation to maintain cell size homeostasis

The paper shows oversized cells increase proteasome-mediated protein degradation to maintain size homeostasis by reducing growth efficiency.

Size-scaling promotes senescence-like changes in proteome and organelle content

The paper investigates how cell size scaling affects proteome organization and organelle content, linking these changes to senescence-like features in human cells.

Cell size homeostasis is maintained by a circuitry involving a CDK4-determined target size that programs the cell size-dependent activation of p38

The paper identifies CDK4 as a regulator of cell size target size, distinct from growth-promoting pathways, and proposes a model linking mTORC1, p38, and CDK4 in cell size homeostasis.

Cell size sensing in animal cells coordinates growth rates and cell cycle progression to maintain cell size uniformity

The paper shows cells adjust growth rates and cell cycle progression to maintain uniform size by sensing their own size and modifying growth and division timing.

Size uniformity of animal cells is actively maintained by a p38 MAPK-dependent regulation of G1-length

The p38 MAPK pathway coordinates cell growth and cell cycle progression by lengthening G1 in small cells, allowing them more time to grow before their next division.