Thymidine rescues ATR kinase inhibition induced deoxyuridine contamination in genomic DNA, cell death, and Type 1 interferon expression
N. Sugitani, F. P. Vendetti, A. J. Cipriano, P. Pandya, J. J. Deppas, T. N. Moiseeva, S. Schamus-Haynes, Y. Wang, D. Palmer, H. U. Osmanbeyoglu, A. Bostwick, N. W. Snyder, Y.-N. Gong, K. M. Aird, G. M. Delgoffe, , C. J. Bakkenist
This study shows that thymidine rescues ATR kinase inhibitor-induced deoxyuridine contamination, cell death, and Type 1 interferon expression in CD8+ T cells.
bioRxiv · Feb 24, 2022 · PreprintCancer Biology