PKC-alpha promotes phosphorylation of KRAS suppressing its oncogenic properties
T. Joglekar, A. Ku, E. Schollaert, Y.-N. Gong, J. Stewart-Ornstein, A. Urisman, M.-T. Wang
This study identifies PKC-alpha as a suppressor of KRAS oncogenic properties through phosphorylation, altering the KRAS-CaM signaling axis in KRAS mutant tumor cells.
bioRxiv · May 24, 2022 · PreprintCancer Biology