Author

J. J. Deppas

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Assay:DNA methylation· 1 Assay:proteomics· 1

Frequent Co-Authors

C. J. Bakkenist· 2 shared F. P. Vendetti· 2 shared J. H. Beumer· 2 shared K. M. Aird· 2 shared P. Pandya· 2 shared A. Bostwick· 1 shared A. J. Cipriano· 1 shared A. V. Columbus· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersCancer Biology

C. J. Bakkenist

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2 papers

Recent·Most cited

Deoxyuridine-rich cytoplasmic DNA antagonizes STING-dependent innate immune responses and sensitizes resistant tumors to anti-PD-L1 therapy

P. Pandya, F. P. Vendetti, J. A. El-Ghoubaira, S. Pathak, J. J. Deppas, R. E. Jones, A. V. Columbus, Y. Zhang, D. Ivanov, Z. Huang, K. M. MacDonald, S. M. Harding, R. Buj, K. M. Aird, J. H. Beumer, , C. J. Bakkenist

The paper shows that dU-rich cytoplasmic DNA inhibits STING-dependent immune responses and enhances anti-PD-L1 therapy efficacy in tumors.

bioRxiv · Apr 4, 2024 · PreprintCancer Biology

Thymidine rescues ATR kinase inhibition induced deoxyuridine contamination in genomic DNA, cell death, and Type 1 interferon expression

N. Sugitani, F. P. Vendetti, A. J. Cipriano, P. Pandya, J. J. Deppas, T. N. Moiseeva, S. Schamus-Haynes, Y. Wang, D. Palmer, H. U. Osmanbeyoglu, A. Bostwick, N. W. Snyder, Y.-N. Gong, K. M. Aird, G. M. Delgoffe, , C. J. Bakkenist

This study shows that thymidine rescues ATR kinase inhibitor-induced deoxyuridine contamination, cell death, and Type 1 interferon expression in CD8+ T cells.

bioRxiv · Feb 24, 2022 · PreprintCancer Biology