A. J. Davison

ADAM17 targeting by human cytomegalovirus remodels the cell surface proteome to simultaneously regulate multiple immune pathways

This paper identifies how HCMV targets ADAM17 to modulate surface proteins and immune pathways, revealing a novel viral immunomodulation strategy.

Human cytomegalovirus protein RL1 degrades the antiviral factor SLFN11 via recruitment of the CRL4 E3 ubiquitin ligase complex

This study identifies HCMV protein RL1 as a viral antagonist that degrades SLFN11 via CRL4 E3 ubiquitin ligase, revealing SLFN11's role in restricting HCMV infection.

Human cytomegalovirus protein pUL36: a dual cell death pathway inhibitor

This paper identifies HCMV protein pUL36 as a dual inhibitor of apoptotic and necroptotic cell death by degrading MLKL and preventing caspase 8 activation.

Human Cytomegalovirus Genomes Sequenced Directly from Clinical Material: Variation, Multiple-Strain Infection, Recombination and Mutation

The paper sequences HCMV genomes from clinical samples to study variation, multiple-strain infection, recombination, and mutation, finding that recombinant strains and pseudogenes can persist and cause congenital infections.

Inherited chromosomally integrated human herpesvirus 6 genomes are ancient, intact and potentially able to reactivate from telomeres

The paper analyzes 28 chromosomally integrated HHV-6 genomes, showing they are ancient, intact, and capable of reactivation, with regional variation and common ancestry in European populations.