Author

J. Nichols

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 6 Cell Biology· 1 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:host-pathogen & immune response· 6 Organism:human· 4 Assay:proteomics· 4 Organism:mouse· 3 Research Focus:differential expression· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

A. J. Davison· 3 shared K. Nightingale· 3 shared L. Nobre· 3 shared R. J. Stanton· 3 shared A. da Silva Filipe· 2 shared C. A. Fielding· 2 shared E. C. Y. Wang· 2 shared K. Nomikou· 2 shared

Activity by Year

2017-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersMicrobiology

A. J. Davison

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Comparative study of two Rift Valley fever virus field strains circulating in Mauritania in 2010 and 2013 reveals the high virulence of the MRU25010-30 strain isolated from camel

M. Chabert, S. Lacote, P. Marianneau, M.-P. Confort, N. Aurine, A. Pedarrieu, B. Doumbia, M. Ould Baba Ould Gueya, H. Habiboullah, A. B. Ould El Mamy, M. M. Lo, J. Nichols, V. B. Sreenu, A. da Silva Filipe, M.-A. Colle, , M. Ratinier

This study compares two Rift Valley fever virus strains from Mauritania, showing that MRU25010-30 is more virulent and replicates more efficiently than MRU2687-3.

bioRxiv · Apr 3, 2024 · PreprintMicrobiology

A Machine Learning Framework to Identify the Correlates of Disease Severity in Acute Arbovirus Infection

V. Herder, M. Caporale, O. MacLean, D. Pintus, X. Huang, K. Nomikou, N. Palmalux, J. Nichols, R. Scivoli, C. Boutell, A. Taggart, J. Allan, H. Malik, G. Ilia, Q. Gu, , M. Palmarini

This study uses machine learning to identify key viral and host processes associated with varying severity in bluetongue virus infection in sheep.

bioRxiv · Feb 23, 2024 · PreprintMicrobiology

Thymic epithelial cell fate and potency in early organogenesis assessed by single cell transcriptional and functional analysis.

A. Chengrui, A. M. Farley, S. Palmer, D. Liu, A. I. Kousa, P. Rouse, V. Major, J. Sweetman, J. Morys, A. Corsinotti, J. Nichols, J. Ure, R. McLay, L. Boulter, J. S. Chapman, , C. C. Blackburn

The paper uses single-cell RNA sequencing to analyze thymic epithelial cell fate and potency in early mouse thymus development, revealing sublineage-primed progenitors and functional bipotency changes.

bioRxiv · Jun 7, 2023 · PreprintDevelopmental Biology

ADAM17 targeting by human cytomegalovirus remodels the cell surface proteome to simultaneously regulate multiple immune pathways

A. Rubina, M. Patel, K. Nightingale, M. Potts, C. A. Fielding, S. Kollnberger, B. Lau, K. Ladell, K. L. Miners, J. Nichols, L. Nobre, D. Roberts, T. M. Trinca, J. P. Twohig, V.-M. Vlahava, , E. C. Y. Wang

This paper identifies how HCMV targets ADAM17 to modulate surface proteins and immune pathways, revealing a novel viral immunomodulation strategy.

bioRxiv · Mar 16, 2023Microbiology

Human cytomegalovirus protein RL1 degrades the antiviral factor SLFN11 via recruitment of the CRL4 E3 ubiquitin ligase complex

K. Nightingale, C. A. Fielding, C. Zerbe, L. Hunter, M. Potts, A. Fletcher-Etheringon, L. Nobre, E. C. Y. Wang, B. L. Strang, J. Houghton, R. Antrobus, N. M. Suarez, J. Nichols, A. J. Davison, R. J. Stanton, M. P. Weekes

This study identifies HCMV protein RL1 as a viral antagonist that degrades SLFN11 via CRL4 E3 ubiquitin ligase, revealing SLFN11's role in restricting HCMV infection.

bioRxiv · May 14, 2021Microbiology

The circulating SARS-CoV-2 spike variant N439K maintains fitness while evading antibody-mediated immunity

E. C. Thomson, L. E. Rosen, J. G. Shepherd, R. Spreafico, A. da Silva Filipe, J. A. Wojcechowskyj, C. Davis, L. Piccoli, D. J. Pascall, J. Dillen, S. Lytras, N. Czudnochowski, R. Shah, M. Meury, N. Jesudason, , J. Nichols

The paper shows the N439K SARS-CoV-2 spike variant maintains replication fitness while evading antibody neutralization.

bioRxiv · Nov 4, 2020Microbiology

Human cytomegalovirus protein pUL36: a dual cell death pathway inhibitor

A. Fletcher-Etherington, L. Nobre, K. Nightingale, R. J. Antrobus, J. Nichols, A. J. Davison, R. J. Stanton, M. P. Weekes

This paper identifies HCMV protein pUL36 as a dual inhibitor of apoptotic and necroptotic cell death by degrading MLKL and preventing caspase 8 activation.

bioRxiv · Feb 3, 2020Microbiology

A lncRNA/Lin28/Let7 Axis Coupled To DNA Methylation Fine Tunes The Dynamics Of A Cell State Transition

M. A. Li, P. P. Amaral, P. Cheung, J. H. Bergmann, M. Kinoshita, T. Kalkan, M. Ralser, S. Robson, F. von Meyenn, M. Paramor, F. Yang, C. Chen, J. Nichols, D. L. Spector, T. Kouzarides, , A. Smith

The paper identifies a lncRNA/miRNA/DNA methylation axis that regulates the timing of stem cell state transition from naive pluripotency.

bioRxiv · Apr 26, 2017Cell Biology