M. P. Weekes

Epstein-Barr Virus BALF0/1 Subverts the Caveolin and ERAD Pathways to Target B-cell Receptor Complexes for Degradation

This paper identifies that EBV's BALF0/1 protein degrades B-cell receptor complexes by subverting caveolin and ERAD pathways, enhancing viral secretion.

Highly Multiplexed Proteomic Analysis of HCMV-Infected Dendritic Cells Reveals Global Manipulation of Adaptive Immunity and Host Restriction of Viral Replication

The paper uses proteomic analysis to study HCMV-infected dendritic cells, revealing how the virus manipulates adaptive immunity and restricts replication.

Spatial proteomics identifies a novel CRTC-dependent viral sensing pathway that stimulates production of Interleukin-11

The paper identifies a novel CRTC-dependent viral sensing pathway that promotes interleukin-11 production during viral infection.

Large-scale proteomic analysis of T. spiralis muscle-stage ESPs identifies a novel upstream motif for in silico prediction of secreted products

This study identifies a novel upstream motif in T. spiralis muscle-stage ESPs that can predict secreted proteins, using proteomic and computational methods.

Selective modulation of cell surface proteins during vaccinia infection: implications for immune evasion strategies

This study quantifies PM protein modulation during vaccinia infection, identifying downregulated immune ligands and upregulated decoy receptors, revealing immune evasion strategies.

IFITM3 regulates virus-induced inflammatory cytokine production by titrating Nogo-B orchestration of TLR responses

This study shows IFITM3 limits viral pathogenesis by regulating Nogo-B-mediated TLR responses and cytokine production in dendritic cells.

A co-opted ISG15-USP18 binding mechanism normally reserved for deISGylation controls type I IFN signalling

The paper identifies a new function of ISG15 in stabilizing USP18 through non-covalent interactions, revealing a mechanism that controls type I IFN signalling.

Human cytomegalovirus protein RL1 degrades the antiviral factor SLFN11 via recruitment of the CRL4 E3 ubiquitin ligase complex

This study identifies HCMV protein RL1 as a viral antagonist that degrades SLFN11 via CRL4 E3 ubiquitin ligase, revealing SLFN11's role in restricting HCMV infection.

Comprehensive cell surface proteomics defines markers of classical, intermediate and non-classical monocytes

The paper identifies cell surface protein markers for classical, intermediate, and non-classical monocytes using mass spectrometry and biotinylation.

Human cytomegalovirus protein pUL36: a dual cell death pathway inhibitor

This paper identifies HCMV protein pUL36 as a dual inhibitor of apoptotic and necroptotic cell death by degrading MLKL and preventing caspase 8 activation.

Herpes simplex virus-1 pUL56 degrades GOPC to alter the plasma membrane proteome

This study identifies HSV-1 pUL56 as a protein that degrades GOPC, altering the plasma membrane proteome by affecting signaling receptors.

Temporal proteomic analysis of BK polyomavirus infection reveals virus-induced G2 arrest and highly effective evasion of innate immune sensing

This study uses temporal proteomic analysis to show BKPyV induces G2 arrest and evades innate immune sensing during infection.