Author

J. Houghton

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Immunology· 2 Cell Biology· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 6 Research Focus:host-pathogen & immune response· 4 Research Focus:cell type annotation· 3 Assay:proteomics· 3 Research Focus:differential expression· 2 Assay:metagenomics· 2 Organism:mouse· 2

Frequent Co-Authors

R. Antrobus· 3 shared C. h. Roberts· 2 shared M. J. Holland· 2 shared M. P. Weekes· 2 shared A. D'Halluin· 1 shared A. Derr· 1 shared A. Fletcher-Etheringon· 1 shared A. Goncalves· 1 shared

Activity by Year

2017-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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3 shared papersCell Biology

R. Antrobus

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

CIPK-B is essential for salt stress signalling in Marchantia polymorpha

C. Tansley, J. Houghton, A. M. E. Rose, B. Witek, R. D. Payet, T. Wu, J. B. Miller

This study identifies CBL-CIPKs in Marchantia polymorpha and shows that CIPK-B is essential for salt stress signaling, forming part of an evolutionarily conserved SOS pathway.

bioRxiv · Aug 22, 2022Plant Biology

The exocyst complex is an essential component of the mammalian constitutive secretory pathway

C. Pereira, D. Stalder, G. Anderson, A. S. Shun-Shion, J. Houghton, R. Antrobus, M. A. Chapman, D. J. Fazakerley, D. C. Gershlick

This study identifies the exocyst complex as essential for constitutive secretion in mammalian cells by showing its role in carrier fusion and cargo delivery.

bioRxiv · May 26, 2022 · PreprintCell Biology

Human cytomegalovirus protein RL1 degrades the antiviral factor SLFN11 via recruitment of the CRL4 E3 ubiquitin ligase complex

K. Nightingale, C. A. Fielding, C. Zerbe, L. Hunter, M. Potts, A. Fletcher-Etheringon, L. Nobre, E. C. Y. Wang, B. L. Strang, J. Houghton, R. Antrobus, N. M. Suarez, J. Nichols, A. J. Davison, R. J. Stanton, M. P. Weekes

This study identifies HCMV protein RL1 as a viral antagonist that degrades SLFN11 via CRL4 E3 ubiquitin ligase, revealing SLFN11's role in restricting HCMV infection.

bioRxiv · May 14, 2021Microbiology

The Mycobacterium tuberculosis sRNA F6 modifies expression of essential chaperonins, GroEL2 and GroES

J. Houghton, A. Rodgers, G. Rose, A. D'Halluin, T. Kipkorir, D. Barker, S. Waddell, K. B. Arnvig

This study identifies the M. tuberculosis sRNA F6 as a regulator of chaperonin expression under starvation conditions, suggesting a role in long-term survival.

bioRxiv · Jul 15, 2020Microbiology

Comprehensive cell surface proteomics defines markers of classical, intermediate and non-classical monocytes

B. J. Ravenhill, L. Soday, J. Houghton, R. Antrobus, M. P. Weekes

The paper identifies cell surface protein markers for classical, intermediate, and non-classical monocytes using mass spectrometry and biotinylation.

bioRxiv · Feb 20, 2020Immunology

Conjunctival microbiome-host responses are associated with impaired epithelial cell health in both early and late stages of trachoma

H. Pickering, C. D. Palmer, J. Houghton, P. Makalo, H. Joof, T. Derrick, A. Goncalves, D. C. Mabey, R. L. Bailey, M. J. Burton, C. h. Roberts, S. E. Burr, M. J. Holland

This study links changes in the conjunctival microbiome and host immune responses to impaired epithelial cell health in trachoma, with distinct patterns in active trachoma and scarring trachoma.

bioRxiv · Jun 13, 2019Microbiology

HIV-1-induced cytokines deplete homeostatic ILCs and expand TCF7-dependent memory NK cells

Y. Wang, K. Gellatly, S. McCauley, P. Vangala, K. Kim, A. Derr, S. Jaiswal, A. Kucukural, P. McDonel, L. Lifshitz, T. Greenough, J. Houghton, M. Garber, J. Luban

This study shows HIV-1-induced cytokines deplete homeostatic ILCs and drive the expansion of TCF7-dependent memory NK cells.

bioRxiv · Jan 2, 2019 · PreprintImmunology

Active Trachoma Cases In The Solomon Islands Have Varied Polymicrobial Community Structures But Do Not Associate With Individual Non-Chlamydial Pathogens Of The Eye

R. Butcher, O. Sokana, K. Jack, E. Kalae, L. Sui, C. Russell, J. Houghton, C. Palmer, M. J. Holland, R. Le Mesurier, A. Solomon, D. Mabey, C. h. Roberts

The paper investigates whether active trachoma in the Solomon Islands is linked to non-chlamydial pathogens or polymicrobial dysbiosis, finding no significant association with individual pathogens but noting inter-individual microbiome variation.

bioRxiv · Oct 10, 2017Microbiology