Author

A. J. George

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

K. M. Parsons· 2 shared R. D. Hannan· 2 shared A. Braithwaite· 1 shared C. Engel· 1 shared C. M. Gould· 1 shared C. Montellese· 1 shared C. V. Chin· 1 shared G. Burgio· 1 shared

Activity by Year

2020-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersCell Biology

K. M. Parsons

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Nuclear stabilisation of p53 requires a functional nucleolar surveillance pathway

K. M. Hannan, P. Soo, M. S. Wong, J. K. Lee, N. Hein, M. Evers, K. D. Wysoke, T. D. Williams, C. Montellese, L. Smith, S. J. Al-Obaidi, L. Nunez-Villacis, P. Poh, M. Pavy, J.-S. He, , A. J. George

This study identifies the nucleolar surveillance pathway (NSP) as a central regulator of p53 stability, showing its role in integrating various cellular stresses and its potential as a therapeutic target in cancer.

bioRxiv · Jan 21, 2021 · PreprintCell Biology

Cohesin mutations are synthetic lethal with stimulation of WNT signaling

C. V. Chin, J. Antony, S. Ketharnathan, G. Gimenez, K. M. Parsons, J. He, A. J. George, A. Braithwaite, P. Guilford, R. D. Hannan, J. A. Horsfield

The paper identifies GSK3 inhibitors as synthetic lethal with cohesin mutations, revealing Wnt pathway activation as a therapeutic target in cohesin mutant cancers.

bioRxiv · Jul 23, 2020Cancer Biology