A rewiring of the earliest immune events leading to T-cell mediated disease following intestinal infection in a PINK1 knock out mouse model of Parkinsons disease
S. Recinto, A. Kazanova, E. Afanasiev, A. MacDonald, S. Premachandran, A. Allot, H. Bessaiah, B. Cordeiro, S. Mukherjee, J. Pei, H. M. McBride, L.-E. Trudeau, S. Gruenheid, J. A. Stratton
This study identifies early immune dysregulation in PINK1 KO mice following intestinal infection, showing myeloid cell activation and T cell response as key factors in PD-like disease progression.
bioRxiv · Jun 18, 2024Immunology