S. Gruenheid

Modeling gene-environment interactions in Parkinson's Disease: Helicobacter pylori infection of Pink1-/- mice induces CD8 T cell-dependent motor and cognitive dysfunction.

This study shows that Helicobacter pylori infection in Pink1-/- mice causes motor and cognitive dysfunction linked to CD8 T cell activity, mimicking early PD features.

LRRK2 regulates the activation of the unfolded protein response and antigen presentation in macrophages during inflammation

This study identifies LRRK2 as a regulator of the unfolded protein response and antigen presentation in macrophages during inflammation, linking it to immune response mechanisms.

Simulated colonic fluid replicates the in vivo growth capabilities of Citrobacter rodentium cpxRA mutants and uncovers additive effects of Cpx regulated genes on fitness

This study shows that C. rodentium cpxRA mutants have reduced colonization and virulence in mice, mirroring their growth defects in simulated colonic fluid, suggesting that multiple Cpx-regulated genes collectively impact fitness.

A Mediterranean-like fat blend protects against the development of severe colitis in the mucin-2 deficient murine model

The study compares the effects of a Mediterranean-like fat blend to other diets in Muc2-/- mice, finding it reduces colitis severity and promotes beneficial gut microbes.

Simulated colonic fluid replicates the in vivo growth capabilities of Citrobacter rodentium mutants and highlights a critical role for the Cpx envelope stress response in mediating stressors encountered in the gastrointestinal tract

The paper shows that Cpx envelope stress response mutants of Citrobacter rodentium have growth defects in simulated colonic fluid and reduced virulence in mice.

Identification and characterization of OmpT-like proteases in uropathogenic Escherichia coli clinical isolates

The paper measures OmpT protease activity in UPEC isolates and finds higher activity in symptomatic UTI strains, with some isolates also expressing an additional ompT-like gene, arlC.