J. Sung

Modeling gene-environment interactions in Parkinson's Disease: Helicobacter pylori infection of Pink1-/- mice induces CD8 T cell-dependent motor and cognitive dysfunction.

This study shows that Helicobacter pylori infection in Pink1-/- mice causes motor and cognitive dysfunction linked to CD8 T cell activity, mimicking early PD features.

Single-molecule analysis of specificity and multivalency in binding of short linear substrate motifs to the APC/C

The paper develops a single-molecule assay to study SLiM binding to APC/C and finds distinct affinities and multivalency in substrate recognition.

Cytolytic memory CD4+ T cell clonotypes are expanded during Plasmodium falciparum infection

The paper identifies clonally expanded cytolytic memory CD4+ T cells in Plasmodium falciparum malaria patients and links their reduced chemotactic and inhibitory receptor expression to clinical immunity.

Sensitivity of radio-photoluminescence glass dosimeters to accumulated doses

This study examines how accumulated doses affect radio-photoluminescence glass dosimeters (RPLGDs) under different photon energies and irradiation conditions.

Cryptococcus deuterogattii VGIIa infection associated with travel to the Pacific Northwest outbreak region in an anti-GM-CSF autoantibody positive patient in the United States

This paper reports a case of C. deuterogattii VGIIa infection in a U.S. patient linked to travel to the PNW outbreak region and associated with anti-GM-CSF autoantibodies.

High accuracy measurements of nanometer-scale distances between fluorophores at the single-molecule level

The paper introduces a two-color localization method to measure nanometer-scale distances between fluorophores with high accuracy, revealing a 4 nm conformational change in dynein.

TMEM16F activation by Ca2+ triggers plasmalemma expansion and directs PD-1 trafficking

This study shows TMEM16F activation by Ca2+ causes surface membrane expansion and PD-1 trafficking in T cells.

Insulin resistance in cavefish as an adaptation to a nutrient-limited environment

This study shows cavefish have insulin resistance due to a mutation in the insulin receptor, which may confer advantages in nutrient-limited environments despite negative effects seen in humans.