This study identifies RIP140 as a regulator of IFNγ signaling in breast cancer, showing its repression of IFNγ-induced GBP1 expression and its role in enhancing IFNγ's anti-tumor effects.

bioRxiv · Feb 15, 2024Cancer Biology

Parallelized Acquisition of Orbitrap and Astral Analyzers Enables High-Throughput Quantitative Analysis.

H. Stewart, D. Grinfeld, A. Giannakopulos, J. Petzoldt, T. Shanley, M. Garland, E. Denisov, A. Peterson, E. Damoc, M. Zeller, T. Arrey, A. Pashkova, S. Renuse, A. Hakimi, A. Kuehn, , C. Hock

The paper introduces a new hybrid mass spectrometer combining Orbitrap and Astral analyzers to enable faster and more sensitive high-resolution accurate mass MS/MS spectra acquisition for proteomics.

bioRxiv · Jun 2, 2023Cell Biology

A trade-off between stress resistance and tolerance underlies the adaptive response to hydrogen peroxide

B. Jacquel, B. Kavcic, T. Aspert, A. Kuehn, A. Zhuralev, E. Byckov, A. Matifas, B. Morgan, T. Julou, G. Charvin

This study identifies a trade-off between stress resistance and tolerance in budding yeast and bacteria during the response to hydrogen peroxide, showing that reducing resistance increases tolerance.

bioRxiv · Apr 23, 2021Cell Biology