B. Morgan

Tsa1 is the dominant peroxide scavenger and a source of H2O2-dependent GSSG production in yeast

This study identifies Tsa1 as the primary peroxide scavenger in yeast and shows it can generate GSSG under H2O2 conditions.

Pancreatic islets undergo functional and morphological adaptation during development of Barth Syndrome

The paper investigates how defective cardiolipin remodeling in Barth Syndrome affects pancreatic islet function and metabolism, finding improved glucose tolerance and compensatory metabolic adaptations in a mouse model.

The ER Thioredoxin-Related Transmembrane Protein TMX2 Controls Redox-Mediated Tethering of ER-Mitochondria Contacts (ERMCS)

This paper identifies TMX2 as a regulator of ER-mitochondria contacts by preventing TOM70 sulfenylation, linking its dysfunction to neurodevelopmental disorders.

The NAPstar family of NADP redox state sensors highlights glutathione as the primary mediator of anti-oxidative electron flux

The paper introduces NAPstar biosensors to measure NADP redox states and finds glutathione mediates anti-oxidative electron flux across eukaryotes.

The role of glutathione in periplasmic redox homeostasis and oxidative protein folding in Escherichia coli

This study investigates the role of glutathione in periplasmic redox homeostasis and oxidative protein folding in E. coli using genetically encoded redox probes.

The metabolite-controlled ubiquitin conjugase Ubc8 promotes mitochondrial protein import by enhancing assembly of the TOM complex

This study shows that Ubc8 promotes mitochondrial protein import by enhancing TOM complex assembly during metabolic transitions in yeast.

Thioredoxin reductase controls the capacity of peroxiredoxins to limit mitochondrial H2O2 release

The paper investigates mitochondrial H2O2 release in mammalian cells and finds that peroxiredoxins 1 and 2 control H2O2 gradients and handling through dynamic adaptation of thioredoxin reductase.

A trade-off between stress resistance and tolerance underlies the adaptive response to hydrogen peroxide

This study identifies a trade-off between stress resistance and tolerance in budding yeast and bacteria during the response to hydrogen peroxide, showing that reducing resistance increases tolerance.

Real-time monitoring of subcellular H2O2 distribution in Chlamydomonas reinhardtii

The paper develops genetically encoded H2O2 sensors for subcellular monitoring in Chlamydomonas reinhardtii and shows H2O2 gradients and temperature-dependent cytosolic levels.

Restriction of essential amino acids dictates the systemic response to dietary protein dilution

This study shows that restricting essential amino acids, not non-essential ones, drives systemic metabolic responses to dietary protein dilution and genetic amino acid transport loss.