Author

R. A. Brown

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 2 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Assay:CITE-seq· 1 Research Focus:clustering· 1

Frequent Co-Authors

A. K. Grosskopf· 2 shared C. L. Maikawa· 2 shared E. C. Gale· 2 shared S. Correa· 2 shared A. Briegel· 1 shared A. L. S. Chang· 1 shared A. Sturm· 1 shared A. T. Mayer· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersBioengineering

A. K. Grosskopf

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Antibiotic action revealed by real-time imaging of the mycobacterial membrane

M. G. Wuo, C. L. Dulberger, R. A. Brown, A. Sturm, E. Ultee, Z. Bloom-Ackermann, C. Choi, E. C. Garner, A. Briegel, D. T. Hung, E. J. Rubin, L. L. Kiessling

This study uses real-time imaging to observe how antibiotics affect mycobacterial cell envelope remodeling, revealing unique cellular responses and extracellular vesicle production.

bioRxiv · Jan 7, 2022 · PreprintMicrobiology

Injectable Nanoparticle-Based Hydrogels Enable the Safe and Effective Deployment of Immunostimulatory CD40 Agonist Antibodies

S. Correa, E. C. Gale, A. T. Mayer, Z. Xiao, C. Liong, J. H. Klich, R. A. Brown, E. L. Meany, O. M. Saouaf, C. L. Maikawa, A. K. Grosskopf, J. L. Mann, J. Idoyaga, E. Appel

This paper develops injectable hydrogels to safely deliver CD40 agonist antibodies, reducing toxicity while maintaining anti-cancer efficacy in a melanoma model.

bioRxiv · Jun 27, 2021Bioengineering

Consistent Tumorigenesis with Self-Assembled Hydrogels Enables High-powered Murine Cancer Studies

A. K. Grosskopf, S. Correa, J. Baillet, C. L. Maikawa, E. C. Gale, R. A. Brown, E. A. Appel

This paper introduces a hydrogel-based tumor inoculation method that reduces variability in murine tumor growth, enabling more efficient and reliable cancer studies.

bioRxiv · Apr 13, 2021Bioengineering

Clonal replacement of tumor-specific T cells following PD-1 blockade

K. E. Yost, A. T. Satpathy, D. K. Wells, Y. Qi, C. Wang, R. Kageyama, K. McNamara, J. M. Granja, K. Y. Sarin, R. A. Brown, R. K. Gupta, C. Curtis, S. L. Bucktrout, M. M. Davis, A. L. S. Chang, H. Y. Chang

This study tracks T cell clonal dynamics before and after PD-1 blockade in cancer patients, finding that new T cell clones, not pre-existing ones, expand in response to treatment.

bioRxiv · May 24, 2019Immunology