Author

K. E. Yost

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Cancer Biology· 3

Signature Assays, Organisms & Methods

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Approach:statistical model· 7 Approach:experimental assay· 4 Organism:human· 4 Research Focus:cell type annotation· 3 Approach:deep learning· 3 Assay:scRNA-seq· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2

Frequent Co-Authors

B. Daniel· 4 shared A. T. Satpathy· 3 shared H. Y. Chang· 3 shared K. L. Hung· 3 shared P. S. Mischel· 3 shared Y. Qi· 3 shared H. Chang· 2 shared J. C. Rose· 2 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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4 shared papersImmunology

B. Daniel

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Author profile →

7 papers

Recent·Most cited

Disparate pathways for extrachromosomal DNA biogenesis and genomic DNA repair

J. C. Rose, I. T.-L. Wang, B. Daniel, M. G. Jones, K. E. Yost, K. L. Hung, E. J. Curtis, P. S. Mischel, H. Chang

This study uses a CRISPR-based method to investigate ecDNA formation, showing efficient circularization and distinct repair pathways for ecDNA and chromosomal scars.

bioRxiv · Oct 22, 2023Cancer Biology

A unique epigenomic landscape defines CD8+ tissue-resident memory T cells

F. A. Buquicchio, R. Fonseca, J. A. Belk, M. Evrard, A. Obers, Y. Qi, B. Daniel, K. E. Yost, A. T. Satpathy, L. K. Mackay

This study identifies distinct epigenetic trajectories in CD8+ T cells during acute infection, revealing how chromatin accessibility changes guide the development of tissue-resident memory T cells versus circulating memory T cells.

bioRxiv · May 4, 2022 · PreprintImmunology

Divergent clonal differentiation trajectories of T cell exhaustion

B. Daniel, K. E. Yost, K. Sandor, Y. Xia, Y. Qi, K. J. Hiam-Galvez, S. L. Meier, J. Belk, J. R. Giles, E. J. Wherry, H. Chang, T. Egawa, A. Satpathy

This study identifies divergent clonal differentiation trajectories of T cell exhaustion during chronic viral infection, showing that TCR signal strength determines terminal or KLR Tex fates.

bioRxiv · Dec 16, 2021Immunology

Principles of ecDNA random inheritance drive rapid genome change and therapy resistance in human cancers

J. T. Lange, C. Y. Chen, Y. Pichugin, F. Xie, J. Tang, K. L. Hung, K. E. Yost, Q. Shi, M. L. Erb, U. Rajkumar, S. Wu, C. Swanton, Z. Liu, W. Huang, H. Y. Chang, , P. S. Mischel

bioRxiv · Jun 11, 2021 · PreprintCancer Biology

EcDNA hubs drive cooperative intermolecular oncogene expression

K. L. Hung, K. E. Yost, L. Xie, S. Wu, J. T. Lange, C. V. Duffy, K. Kraft, J. Tang, Q. Shi, J. C. Rose, M. R. Corces, J. M. Granja, R. Li, U. Rajkumar, R. Tjian, , H. Y. Chang

The paper identifies ecDNA hubs as nuclear structures that drive cooperative oncogene expression through intermolecular enhancer-promoter interactions and shows BET inhibitors can disrupt these hubs and kill cancer cells.

bioRxiv · Nov 19, 2020Cancer Biology

Latent Plasticity of Effector-like Exhausted CD8 T cells contributes to memory responses

S. Raju, Y. Xia, B. Daniel, K. E. Yost, E. Bradshaw, E. Tonc, D. J. Verbaro, A. T. Satpathy, T. Egawa

The paper identifies a subset of exhausted CD8 T cells with plasticity to reprogram into memory cells, suggesting new targets for immunotherapy.

bioRxiv · Feb 22, 2020 · PreprintImmunology

Clonal replacement of tumor-specific T cells following PD-1 blockade

K. E. Yost, A. T. Satpathy, D. K. Wells, Y. Qi, C. Wang, R. Kageyama, K. McNamara, J. M. Granja, K. Y. Sarin, R. A. Brown, R. K. Gupta, C. Curtis, S. L. Bucktrout, M. M. Davis, A. L. S. Chang, H. Y. Chang

This study tracks T cell clonal dynamics before and after PD-1 blockade in cancer patients, finding that new T cell clones, not pre-existing ones, expand in response to treatment.

bioRxiv · May 24, 2019Immunology