A. L. Whitford

Single-genome analysis reveals heterogeneous association of the Herpes Simplex Virus genome with H3K27me2 and the reader PHF20L1 following infection of human fibroblasts

This study investigates the association of HSV-1 genomes with H3K27me2 and PHF20L1 in fibroblasts, finding that H3K27me2 is linked to genome silencing and that this association is influenced by demethylase activity and transcriptional state.

c-Jun Signaling During Initial HSV-1 Infection Modulates Latency to Enhance Later Reactivation in addition to Directly Promoting the Progression to Full Reactivation

This study shows c-Jun signaling during HSV-1 initial infection promotes latency and enhances later reactivation by facilitating the transition from Phase I to Phase II reactivation.

HSV-1 miRNAs are posttranscriptionaly edited in latently infected human ganglia

The paper identifies posttranscriptional A-to-I hyperediting of HSV-1 miR-H2 in latently infected human ganglia, expanding its targeting potential and suggesting a role in regulating viral latency.

Herpes Simplex Virus Reactivation Induced Ex Vivo Involves a DLK-Dependent but Histone Demethylase-Independent Wave of Lytic Gene Expression

This study shows that HSV-1 reactivation ex vivo involves DLK-dependent but histone demethylase-independent lytic gene expression, preceding infectious virus production.