C. Boutell

Single-genome analysis reveals heterogeneous association of the Herpes Simplex Virus genome with H3K27me2 and the reader PHF20L1 following infection of human fibroblasts

This study investigates the association of HSV-1 genomes with H3K27me2 and PHF20L1 in fibroblasts, finding that H3K27me2 is linked to genome silencing and that this association is influenced by demethylase activity and transcriptional state.

A Machine Learning Framework to Identify the Correlates of Disease Severity in Acute Arbovirus Infection

This study uses machine learning to identify key viral and host processes associated with varying severity in bluetongue virus infection in sheep.

Temperature elevation synergises with and enhances the type-I IFN-mediated restriction of MPXV

This study shows that fever enhances the host's type-I IFN response to restrict MPXV replication.

Zoonotic avian influenza viruses evade human BTN3A3 restriction

This study identifies BTN3A3 as a human restriction factor that inhibits avian influenza viruses but not human IAVs, with resistance linked to specific NP mutations.

Superinfection exclusion creates spatially distinct influenza virus populations

This study shows that superinfection exclusion (SIE) creates spatially distinct influenza virus populations, limiting genome interactions between virus subpopulations as they spread within host tissues.

PML-Dependent Memory of Type I Interferon Treatment Results in a Restricted Form of HSV Latency

This study shows that type I interferon treatment during HSV-1 infection leads to restricted latency by altering viral genome positioning through PML-NBs.

Elevated temperature inhibits SARS-CoV-2 replication in respiratory epithelium independently of the induction of IFN-mediated innate immune defences

This study shows that elevated temperatures inhibit SARS-CoV-2 replication in respiratory epithelium without triggering IFN-mediated immune responses.

Neuronal Hyperexcitability is a DLK-dependent Trigger of HSV-1 Reactivation that can be Induced by IL-1

This study shows that neuronal hyperexcitability, induced by IL-1β, triggers HSV-1 reactivation through DLK/JNK pathway and histone phosphorylation.

Constitutive TRIM22 expression within the respiratory tract identifies tissue-specific and cell-type dependent intrinsic immune barriers to influenza A virus infection

This study identifies TRIM22 as a constitutively expressed antiviral factor in the respiratory tract that restricts influenza A virus infection independently of cytokine-mediated immunity.